Literature DB >> 22640698

A case of EBV driven haemophagocytic lymphohistiocytosis complicating a teenage Crohn's disease patient on azathioprine, successfully treated with rituximab.

Michael P Fitzgerald1, Lawrence Armstrong, Rosie Hague, Richard K Russell.   

Abstract

We report a case of Epstein-Barr virus infection with the subsequent development of haemophagocytic lymphohistiocytosis in a teenage Crohn's disease patient treated with azathioprine. We found that the early introduction of the anti-B cell monoclonal antibody rituximab precipitated a rapid fall in circulating B-cells and EBV viral load, resulting in a prompt and sustained recovery from what is a potentially fatal complication of azathioprine therapy in Crohn's disease patients.
Copyright © 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22640698     DOI： 10.1016/j.crohns.2012.05.002

Source DB:  PubMed          Journal:  J Crohns Colitis        ISSN： 1873-9946            Impact factor:   9.071


  9 in total

1.  Increased incidence of systemic serious viral infections in patients with inflammatory bowel disease associates with active disease and use of thiopurines.

Authors:  Andrew Wisniewski; Julien Kirchgesner; Philippe Seksik; Cécilia Landman; Anne Bourrier; Isabelle Nion-Larmurier; Philippe Marteau; Jacques Cosnes; Harry Sokol; Laurent Beaugerie
Journal:  United European Gastroenterol J       Date:  2019-11-14       Impact factor: 4.623

Review 2.  Update on the Use of Thiopurines and Methotrexate in Inflammatory Bowel Disease.

Authors:  Christopher M Johnson; Themistocles Dassopoulos
Journal:  Curr Gastroenterol Rep       Date:  2018-09-28

3.  Crohn's disease complicated by Epstein-Barr virus-driven haemophagocytic lymphohistiocytosis successfully treated with rituximab.

Authors:  Grace Thompson; Dominic Pepperell; Ian Lawrence; Benjamin David McGettigan
Journal:  BMJ Case Rep       Date:  2017-02-22

4.  Prevention of infection caused by immunosuppressive drugs in gastroenterology.

Authors:  Katarzyna Orlicka; Eleanor Barnes; Emma L Culver
Journal:  Ther Adv Chronic Dis       Date:  2013-07       Impact factor: 5.091

Review 5.  Hemophagocytic Lymphohistiocytosis and Inflammatory Bowel Disease: Case Report and Systematic Review.

Authors:  Bárbara Brambilla; Amanda Machado Barbosa; Cassiano da Silva Scholze; Floriano Riva; Lislene Freitas; Raul Angelo Balbinot; Silvana Balbinot; Jonathan Soldera
Journal:  Inflamm Intest Dis       Date:  2020-03-10

6.  Alternative therapy for epstein-barr virus related hemophagocytic lymphohistiocytosis.

Authors:  Omar Al Asad; Amir Salam; Siva Mannem; Mary Ninan; Avi Markowitz; Bagi Jana
Journal:  Case Rep Oncol Med       Date:  2015-02-08

Review 7.  A nearly fatal primary Epstein-Barr virus infection associated with low NK-cell counts in a patient receiving azathioprine: a case report and review of literature.

Authors:  Minna Honkila; Riitta Niinimäki; Mervi Taskinen; Outi Kuismin; Kaisa Kettunen; Janna Saarela; Sami Turunen; Marjo Renko; Terhi Tapiainen
Journal:  BMC Infect Dis       Date:  2019-05-10       Impact factor: 3.090

Review 8.  Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO).

Authors:  Michael B Jordan; Carl E Allen; Jay Greenberg; Michael Henry; Michelle L Hermiston; Ashish Kumar; Melissa Hines; Olive Eckstein; Stephan Ladisch; Kim E Nichols; Carlos Rodriguez-Galindo; Birte Wistinghausen; Kenneth L McClain
Journal:  Pediatr Blood Cancer       Date:  2019-07-24       Impact factor: 3.167

Review 9.  Haemophagocytic lymphohistiocytosis in inflammatory bowel disease with virus infection.

Authors:  Yuan Li; Xuefeng Xia; Jing Zhang; Zhiqiang Song; Liya Zhou; Yaopeng Zhang; Yonghui Huang; Yanyan Shi; Eamonn M M Quigley; Shigang Ding
Journal:  Prz Gastroenterol       Date:  2015-10-02
  9 in total

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