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Literature DB >> 22639679

Changes in immune function in asthma in the elderly.

Abstract

Asthma is an inflammatory disorder of the airway. The airway inflammation of asthma is typically an allergic inflammation characterized by cells and mediators described as a "Th2" inflammatory response. There is a growing body of evidence describing changes in the function of immune cells upon aging, a phenomenon referred to as "immunosenescence". Several studies utilizing animal models and human subjects with asthma have begun to explore age-related effects on the airway inflammation in asthma. This review explores the existing data on the presence and effects of immunosenescence or age-related changes in immune function in asthma.

Entities: Chemical Disease Gene Species

Year: 2009 PMID： 22639679 PMCID： PMC3359620 DOI： 10.2217/ahe.09.47

Source DB: PubMed Journal: Aging health ISSN： 1745-509X

67 in total

Review 1. Homeostasis and the age-associated defect of CD4 T cells.

Authors: Susan Swain; Karen Clise-Dwyer; Laura Haynes
Journal: Semin Immunol Date: 2005-10 Impact factor: 11.130

Review 2. Asthma: defining of the persistent adult phenotypes.

Authors: Sally E Wenzel
Journal: Lancet Date: 2006-08-26 Impact factor: 79.321

3. Sensitization to cat allergen is associated with asthma in older men and predicts new-onset airway hyperresponsiveness. The Normative Aging Study.

Authors: A A Litonjua; D Sparrow; S T Weiss; G T O'Connor; A A Long; J L Ohman
Journal: Am J Respir Crit Care Med Date: 1997-07 Impact factor: 21.405

4. Increasing U.S. asthma mortality rates: who is really dying?

Authors: J E Moorman; D M Mannino
Journal: J Asthma Date: 2001-02 Impact factor: 2.515

5. Effect of age on response to zafirlukast in patients with asthma in the Accolate Clinical Experience and Pharmacoepidemiology Trial (ACCEPT).

Authors: P E Korenblat; J P Kemp; J E Scherger; M C Minkwitz; W Mezzanotte
Journal: Ann Allergy Asthma Immunol Date: 2000-02 Impact factor: 6.347

Review 6. The natural history of asthma.

Authors: Charles E Reed
Journal: J Allergy Clin Immunol Date: 2006-09 Impact factor: 10.793

7. Effects of allergy and age on responses to salbutamol and ipratropium bromide in moderate asthma and chronic bronchitis.

Authors: C P van Schayck; H Folgering; H Harbers; K L Maas; C van Weel
Journal: Thorax Date: 1991-05 Impact factor: 9.139

8. Dysregulation between TH1 and TH2 T cell subpopulations in the elderly.

Authors: I Cakman; J Rohwer; R M Schütz; H Kirchner; L Rink
Journal: Mech Ageing Dev Date: 1996-06-25 Impact factor: 5.432

9. Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice.

Authors: Paula J Busse; Teng Fei Zhang; Kamal Srivastava; Brian Schofield; Xiu-Min Li
Journal: Clin Exp Allergy Date: 2007-09 Impact factor: 5.018