Literature DB >> 226396

Inhibition of hepatic Na +, K + -adenosinetriphosphatase in taurolithocholate-induced cholestasis in the rat.

J Reichen, G Paumgartner.   

Abstract

Na +, K + -adenosinetriphosphatase (Na +, K + -ATPase) activity was decreased in liver plasma membranes from rats in which cholestasis had been induced by i.v. administration of sodium taurolithocholate (5 mumoles/100 g b. wt). Incubation of liver plasma membranes with taurolithocholate (10--1300 muM) caused significant and dose dependent reductions of Na +, K + -ATPase activity at taurolithocholate concentrations above 100 muM. These findings lend support to the hypothesis that cholestasis induced by monohydroxy bile acids is at least partially the result of an inhibition of hepatic Na +, K + -ATPase activity.

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Year:  1979        PMID： 226396     DOI： 10.1007/bf01963278

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  29 in total

1.  Pathogenesis of lithocholate- and taurolithocholate-induced intrahepatic cholestasis in rats.

Authors:  G Kakis; I M Yousef
Journal:  Gastroenterology       Date:  1978-10       Impact factor: 22.682

2.  Cytochemical localization of Na+, K+-ATPase in the rat hepatocyte.

Authors:  B L Blitzer; J L Boyer
Journal:  J Clin Invest       Date:  1978-11       Impact factor: 14.808

Review 3.  The sodium-potassium adenosinetriphosphatase.

Authors:  J L Dahl; L E Hokin
Journal:  Annu Rev Biochem       Date:  1974       Impact factor: 23.643

4.  Fractionation of liver plasma membranes prepared by zonal centrifugation.

Authors:  W H Evans
Journal:  Biochem J       Date:  1970-03       Impact factor: 3.857

5.  Determination of protein: a modification of the Lowry method that gives a linear photometric response.

Authors:  E F Hartree
Journal:  Anal Biochem       Date:  1972-08       Impact factor: 3.365

6.  Effect of phenobarbital on bile flow and bile salt excretion in the rat.

Authors:  G Paumgartner; W Horak; P Probst; G Grabner
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1971

7.  Biochemical and morphological parameters of taurolithocholate-induced cholestasis.

Authors:  B G Priestly; M G Côté; G L Plaa
Journal:  Can J Physiol Pharmacol       Date:  1971-12       Impact factor: 2.273

8.  Effect of inhibitors of sodium transport on bile formation in the rabbit.

Authors:  S Erlinger; D Dhumeaux; P Berthelot; M Dumont
Journal:  Am J Physiol       Date:  1970-08

9.  Stimulation of hepatic sodium and potassium-activated adenosine triphosphatase activity by phenobarbital. Its possible role in regulation of bile flow.

Authors:  F R Simon; E Sutherland; L Accatino
Journal:  J Clin Invest       Date:  1977-05       Impact factor: 14.808

10.  Cholesterol in acute cholestasis induced by taurolithocholic acid. A cytochemical study in transmission and scanning electron microscopy.

Authors:  F Bonvicini; A Gautier; D Gardiol; G A Borel
Journal:  Lab Invest       Date:  1978-04       Impact factor: 5.662
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  4 in total

1.  Taurolithocholate impairs bile canalicular motility and canalicular bile secretion in isolated rat hepatocyte couplets.

Authors:  Norihito Watanabe; Tatehiro Kagawa; Seiichiro Kojima; Shinji Takashimizu; Naruhiko Nagata; Yasuhiro Nishizaki; Tetsuya Mine
Journal:  World J Gastroenterol       Date:  2006-09-07       Impact factor: 5.742

2.  Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat.

Authors:  F A Crocenzi; A D Mottino; E J Sánchez Pozzi; J M Pellegrino; E A Rodríguez Garay; P Milkiewicz; M Vore; R Coleman; M G Roma
Journal:  Gut       Date:  2003-08       Impact factor: 23.059

3.  [Different effect of taurolithocholate and chenodeoxycholate on structure and function of isolated hepatocytes (author's transl)].

Authors:  J Schölmerich; K Schmidt; B Kremer; M S Becher; W Gerok
Journal:  Klin Wochenschr       Date:  1981-06-15

4.  Lithocholate-3-O-glucuronide-induced cholestasis. A study with congenital hyperbilirubinemic rats and effects of ursodeoxycholate conjugates.

Authors:  H Takikawa; K Minagawa; N Sano; M Yamanaka
Journal:  Dig Dis Sci       Date:  1993-08       Impact factor: 3.199
  4 in total

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