Literature DB >> 22639366

Production of galanthamine by Leucojum aestivum shoots grown in different bioreactor systems.

Anika Schumann1, Strahil Berkov, Diana Claus, André Gerth, Jaume Bastida, Carles Codina.   

Abstract

The production of galanthamine by shoots of Leucojum aestivum grown in different bioreactor systems (shaking and nonshaking batch culture, temporary immersion system, bubble bioreactor, continuous and discontinuous gassing bioreactor) under different culture conditions was studied. The influence of the nutrient medium, weight of inoculum, and size of bioreactor on both growth and galanthamine production was studied. The maximal yield of galanthamine (19.416 mg) was achieved by cultivating the L. aestivum shoots (10 g of fresh inoculum) in a temporary immersion system in a 1-L bioreactor vessel which was used as an airlift culture vessel, gassing 12 times per day (5 min).

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Year:  2012        PMID： 22639366     DOI： 10.1007/s12010-012-9743-3

Source DB:  PubMed          Journal:  Appl Biochem Biotechnol        ISSN： 0273-2289            Impact factor:   2.926


  7 in total

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  7 in total

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