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Literature DB >> 22638939

Pathophysiology of obesity-related renal dysfunction contributes to diabetic nephropathy.

George Bayliss¹, Larry A Weinrauch, John A D'Elia.

Abstract

Recent studies have demonstrated the role of insulin resistance in renal injury related to obesity, with hyperfiltration leading to glomerulomegaly in a pattern similar to that found in diabetic nephropathy. Similarities in the histologic patterns of damage from obesity and diabetes point to overlapping mechanisms of injury. In this review, we will examine the hormonal mechanisms, signaling pathways and injury patterns in renal injury resulting from obesity and attempt to draw conclusions on the reasons for these similarities.

Entities: Disease Gene

Mesh：

Substances：

Year: 2012 PMID： 22638939 DOI： 10.1007/s11892-012-0288-1

Source DB: PubMed Journal: Curr Diab Rep ISSN： 1534-4827 Impact factor: 4.810

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Journal: Ann Transl Med Date: 2021-04