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Literature DB >> 226382

The effects of chemical sympathectomy with 6-hydroxydopamine on alpha-adrenoceptor and muscarinic cholinoceptor binding in rat heart ventricle.

Abstract

The specific binding of 3H-dihydroergocryptine to alpha-adrenoceptors in membranes from the heart ventricle of rats chemically denervated with 6-hydroxydopamine was significantly decreased in comparison with control animals. In contrast the muscarinic cholinoceptor binding of 3H-quinuclinidyl benzilate was unchanged after chemical sympathectomy. These results are interpreted as indicating that the muscarinic receptors are principally postsynaptic but that a significant proportion of the alpha-adrenoceptors are located on noradrenergic nerve terminals.

Entities: Chemical Species

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Year: 1979 PMID： 226382 DOI： 10.1016/0014-2999(79)90505-3

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

9 in total

9. Sympathetic Nerve Stimulation on the perfused rat heart. Affinities of N-methylatropine and pirenzepine at pre- and postsynaptic muscarine receptors.

Authors: H Fuder; D Rink; E Muscholl
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1982-02 Impact factor: 3.000

9 in total

The effects of chemical sympathectomy with 6-hydroxydopamine on alpha-adrenoceptor and muscarinic cholinoceptor binding in rat heart ventricle.

1. One hundred years of adrenaline: the discovery of autoreceptors.

2. Impaired cardiac muscarinic receptor function in dogs with heart failure.

3. Selective additive effect of phenylephrine to the inotropic action of isoproterenol on rabbit left atria.

Review 4. Scintigraphic evaluation of cardiac autonomic innervation.

5. The influence of hormonal and neuronal factors on rat heart adrenoceptors.

6. Presence and axonal transport of cholinoceptor, but not adrenoceptor sites on a cat noradrenergic neurone.

7. Chronic sympathetic denervation increases muscarinic cholinoceptor binding in the rat submaxillary gland.

8. Binding of [3H]-prazosin and [3H]-dihydroergocryptine to rat cardiac alpha-adrenoceptors.

9. Sympathetic Nerve Stimulation on the perfused rat heart. Affinities of N-methylatropine and pirenzepine at pre- and postsynaptic muscarine receptors.