Literature DB >> 22635379

The genetics of dementia with Lewy bodies: what are we missing?

Bram Meeus1, Jessie Theuns, Christine Van Broeckhoven.   

Abstract

Dementia with Lewy bodies is a complex brain disorder and a key member of the Lewy body disease spectrum. Its genetic etiology is unclear, and information is scattered. However, the results of molecular genetic studies imply a genetic and mechanistic overlap with Alzheimer disease, Parkinson disease with dementia, and Parkinson disease. In this review, we provide a comprehensive overview of the current studies on dementia with Lewy bodies heritability, genetic etiology, and genetic heterogeneity. We conclude with a critical discussion of the missing heritability in dementia with Lewy bodies and encourage scientists to further explore the underlying mechanisms of this disease.

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Year:  2012        PMID： 22635379     DOI： 10.1001/archneurol.2011.3678

Source DB:  PubMed          Journal:  Arch Neurol        ISSN： 0003-9942


  16 in total

Review 1.  Young-onset dementia.

Authors:  Dulanji K Kuruppu; Brandy R Matthews
Journal:  Semin Neurol       Date:  2013-11-14       Impact factor: 3.420

Review 2.  Genetics and underlying pathology of dementia.

Authors:  Beata Ferencz; Lotte Gerritsen
Journal:  Neuropsychol Rev       Date:  2015-01-08       Impact factor: 7.444

3.  Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration.

Authors:  Chin Hong Tan; Luke W Bonham; Chun Chieh Fan; Elizabeth C Mormino; Leo P Sugrue; Iris J Broce; Christopher P Hess; Jennifer S Yokoyama; Gil D Rabinovici; Bruce L Miller; Kristine Yaffe; Gerard D Schellenberg; Karolina Kauppi; Dominic Holland; Linda K McEvoy; Walter A Kukull; Duygu Tosun; Michael W Weiner; Reisa A Sperling; David A Bennett; Bradley T Hyman; Ole A Andreassen; Anders M Dale; Rahul S Desikan
Journal:  Brain       Date:  2019-02-01       Impact factor: 13.501

4.  Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes.

Authors:  Luke W Bonham; Daniel S Evans; Yongmei Liu; Steven R Cummings; Kristine Yaffe; Jennifer S Yokoyama
Journal:  Am J Alzheimers Dis Other Demen       Date:  2018-01-16       Impact factor: 2.035

5.  A novel SNCA E83Q mutation in a case of dementia with Lewy bodies and atypical frontotemporal lobar degeneration.

Authors:  Alifiya Kapasi; Jared R Brosch; Kelly N Nudelman; Sonal Agrawal; Tatiana M Foroud; Julie A Schneider
Journal:  Neuropathology       Date:  2020-08-12       Impact factor: 1.906

6.  Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.

Authors:  Ruth Chia; Marya S Sabir; Sara Bandres-Ciga; Sara Saez-Atienzar; Regina H Reynolds; Emil Gustavsson; Ronald L Walton; Sarah Ahmed; Coralie Viollet; Jinhui Ding; Mary B Makarious; Monica Diez-Fairen; Makayla K Portley; Zalak Shah; Yevgeniya Abramzon; Dena G Hernandez; Cornelis Blauwendraat; David J Stone; John Eicher; Laura Parkkinen; Olaf Ansorge; Lorraine Clark; Lawrence S Honig; Karen Marder; Afina Lemstra; Peter St George-Hyslop; Elisabet Londos; Kevin Morgan; Tammaryn Lashley; Thomas T Warner; Zane Jaunmuktane; Douglas Galasko; Isabel Santana; Pentti J Tienari; Liisa Myllykangas; Minna Oinas; Nigel J Cairns; John C Morris; Glenda M Halliday; Vivianna M Van Deerlin; John Q Trojanowski; Maurizio Grassano; Andrea Calvo; Gabriele Mora; Antonio Canosa; Gianluca Floris; Ryan C Bohannan; Francesca Brett; Ziv Gan-Or; Joshua T Geiger; Anni Moore; Patrick May; Rejko Krüger; David S Goldstein; Grisel Lopez; Nahid Tayebi; Ellen Sidransky; Lucy Norcliffe-Kaufmann; Jose-Alberto Palma; Horacio Kaufmann; Vikram G Shakkottai; Matthew Perkins; Kathy L Newell; Thomas Gasser; Claudia Schulte; Francesco Landi; Erika Salvi; Daniele Cusi; Eliezer Masliah; Ronald C Kim; Chad A Caraway; Edwin S Monuki; Maura Brunetti; Ted M Dawson; Liana S Rosenthal; Marilyn S Albert; Olga Pletnikova; Juan C Troncoso; Margaret E Flanagan; Qinwen Mao; Eileen H Bigio; Eloy Rodríguez-Rodríguez; Jon Infante; Carmen Lage; Isabel González-Aramburu; Pascual Sanchez-Juan; Bernardino Ghetti; Julia Keith; Sandra E Black; Mario Masellis; Ekaterina Rogaeva; Charles Duyckaerts; Alexis Brice; Suzanne Lesage; Georgia Xiromerisiou; Matthew J Barrett; Bension S Tilley; Steve Gentleman; Giancarlo Logroscino; Geidy E Serrano; Thomas G Beach; Ian G McKeith; Alan J Thomas; Johannes Attems; Christopher M Morris; Laura Palmer; Seth Love; Claire Troakes; Safa Al-Sarraj; Angela K Hodges; Dag Aarsland; Gregory Klein; Scott M Kaiser; Randy Woltjer; Pau Pastor; Lynn M Bekris; James B Leverenz; Lilah M Besser; Amanda Kuzma; Alan E Renton; Alison Goate; David A Bennett; Clemens R Scherzer; Huw R Morris; Raffaele Ferrari; Diego Albani; Stuart Pickering-Brown; Kelley Faber; Walter A Kukull; Estrella Morenas-Rodriguez; Alberto Lleó; Juan Fortea; Daniel Alcolea; Jordi Clarimon; Mike A Nalls; Luigi Ferrucci; Susan M Resnick; Toshiko Tanaka; Tatiana M Foroud; Neill R Graff-Radford; Zbigniew K Wszolek; Tanis Ferman; Bradley F Boeve; John A Hardy; Eric J Topol; Ali Torkamani; Andrew B Singleton; Mina Ryten; Dennis W Dickson; Adriano Chiò; Owen A Ross; J Raphael Gibbs; Clifton L Dalgard; Bryan J Traynor; Sonja W Scholz
Journal:  Nat Genet       Date:  2021-02-15       Impact factor: 38.330

Review 7.  Genetics Underlying Atypical Parkinsonism and Related Neurodegenerative Disorders.

Authors:  Sonja W Scholz; Jose Bras
Journal:  Int J Mol Sci       Date:  2015-10-16       Impact factor: 5.923

8.  Early-onset dementias: diagnostic and etiological considerations.

Authors:  Mario Masellis; Kayla Sherborn; Pedro Neto; Dessa A Sadovnick; Ging-Yuek R Hsiung; Sandra E Black; Sadhana Prasad; Meghan Williams; Serge Gauthier
Journal:  Alzheimers Res Ther       Date:  2013-07-31       Impact factor: 6.982

9.  Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort.

Authors:  Guro Berge; Sigrid B Sando; Arvid Rongve; Dag Aarsland; Linda R White
Journal:  J Neurol Neurosurg Psychiatry       Date:  2014-03-17       Impact factor: 10.154

10.  Genetic Association between Presenilin 2 Polymorphisms and Alzheimer's Disease and Dementia of Lewy Body Type in a Japanese Population.

Authors:  Ayako Suzuki; Nobuto Shibata; Koji Kasanuki; Tomoyuki Nagata; Shunichiro Shinagawa; Nobuyuki Kobayashi; Tohru Ohnuma; Yoshihide Takeshita; Eri Kawai; Toshiki Takayama; Kenya Nishioka; Yumiko Motoi; Nobutaka Hattori; Kazuhiko Nakayama; Hisashi Yamada; Heii Arai
Journal:  Dement Geriatr Cogn Dis Extra       Date:  2016-03-16
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