Literature DB >> 22633932

What is the key environmental trigger in type 1 diabetes--is it viruses, or wheat gluten, or both?

William E Barbeau1.   

Abstract

Prevention and treatment of type 1 diabetes is hampered by the fact that the key environmental trigger(s) of the disease is still unknown. Much of the data on this subject points to two possibilities, viruses and wheat gluten. Viruses appear to be involved as an etiological agent in some cases of type 1 diabetes, particularly in fulminant type 1 diabetes. Further analysis of the data suggests that viruses are not the sole trigger of type 1 diabetes in humans, and that wheat gluten may play a role in initiating the disease. Viruses may be the key environmental trigger in some cases of type 1 diabetes, and wheat gluten in others. Conceivably, some cases of type 1 diabetes might be caused by viruses and wheat gluten acting together as disease triggers.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID: 22633932     DOI: 10.1016/j.autrev.2012.05.003

Source DB:  PubMed          Journal:  Autoimmun Rev        ISSN: 1568-9972            Impact factor:   9.754


  5 in total

Review 1.  Type 1 diabetes in mice and men: gene expression profiling to investigate disease pathogenesis.

Authors:  Linda Yip; C Garrison Fathman
Journal:  Immunol Res       Date:  2014-05       Impact factor: 2.829

Review 2.  Hepatitis C virus infection and type 1 and type 2 diabetes mellitus.

Authors:  Alessandro Antonelli; Silvia Martina Ferrari; Dilia Giuggioli; Andrea Di Domenicantonio; Ilaria Ruffilli; Alda Corrado; Silvia Fabiani; Santino Marchi; Clodoveo Ferri; Ele Ferrannini; Poupak Fallahi
Journal:  World J Diabetes       Date:  2014-10-15

Review 3.  On the pathogenesis of insulin-dependent diabetes mellitus: the role of microbiota.

Authors:  Elena Gianchecchi; Alessandra Fierabracci
Journal:  Immunol Res       Date:  2017-02       Impact factor: 2.829

Review 4.  The Human Microbiota in Endocrinology: Implications for Pathophysiology, Treatment, and Prognosis in Thyroid Diseases.

Authors:  Giovanni Docimo; Angelo Cangiano; Roberto Maria Romano; Marcello Filograna Pignatelli; Chiara Offi; Vanda Amoresano Paglionico; Marilena Galdiero; Giovanna Donnarumma; Vincenzo Nigro; Daniela Esposito; Mario Rotondi; Giancarlo Candela; Daniela Pasquali
Journal:  Front Endocrinol (Lausanne)       Date:  2020-12-04       Impact factor: 5.555

5.  Gene Expression Analysis of the Pre-Diabetic Pancreas to Identify Pathogenic Mechanisms and Biomarkers of Type 1 Diabetes.

Authors:  Linda Yip; Rebecca Fuhlbrigge; Reem Alkhataybeh; C Garrison Fathman
Journal:  Front Endocrinol (Lausanne)       Date:  2020-12-23       Impact factor: 5.555

  5 in total

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