BACKGROUND & AIMS: Available evidence suggests that patients with short bowel syndrome (SBS) might be at risk of vitamins A, D, E and B(1) deficiency. However, there is little clinical data describing the vitamin K status. Therefore, in the present study we aimed to assess the body resources of vitamin K in a subset of SBS patients. METHODS: The study comprised 33 patients aged 1 month to 16 years. PIVKA-II concentrations were determined in all subjects. RESULTS: In all studied subjects, coagulation parameters were normal. PIVKA-II levels indicative of vitamin K deficiency was found in 3 (9.1%) SBS patients. One patient had been receiving an additional intravenous vitamin K dose of 5 mg/week. In all SBS patients with cirrhosis and cholestasis, PIVKA-II concentrations were low (<2 ng/ml). However, all patients with severe liver disease were receiving vitamin K several times a month. CONCLUSIONS: Vitamin K deficiency may appear in SBS patients.
BACKGROUND & AIMS: Available evidence suggests that patients with short bowel syndrome (SBS) might be at risk of vitamins A, D, E and B(1) deficiency. However, there is little clinical data describing the vitamin K status. Therefore, in the present study we aimed to assess the body resources of vitamin K in a subset of SBSpatients. METHODS: The study comprised 33 patients aged 1 month to 16 years. PIVKA-II concentrations were determined in all subjects. RESULTS: In all studied subjects, coagulation parameters were normal. PIVKA-II levels indicative of vitamin K deficiency was found in 3 (9.1%) SBSpatients. One patient had been receiving an additional intravenous vitamin K dose of 5 mg/week. In all SBSpatients with cirrhosis and cholestasis, PIVKA-II concentrations were low (<2 ng/ml). However, all patients with severe liver disease were receiving vitamin K several times a month. CONCLUSIONS:Vitamin K deficiency may appear in SBSpatients.
Authors: Duy T Dao; Lorenzo Anez-Bustillos; Adam M Finkelstein; Paul D Mitchell; Alison A O'Loughlin; Gillian L Fell; Meredith A Baker; Alexis K Potemkin; Kathleen M Gura; Mark Puder Journal: JPEN J Parenter Enteral Nutr Date: 2019-07-07 Impact factor: 4.016
Authors: Jan K Nowak; Urszula Grzybowska-Chlebowczyk; Piotr Landowski; Anna Szaflarska-Poplawska; Beata Klincewicz; Daria Adamczak; Tomasz Banasiewicz; Andrzej Plawski; Jaroslaw Walkowiak Journal: Sci Rep Date: 2014-04-24 Impact factor: 4.379
Authors: Kelly Nijsten; Loïs van der Minnen; Hanke M G Wiegers; Marjette H Koot; Saskia Middeldorp; Tessa J Roseboom; Iris J Grooten; Rebecca C Painter Journal: Br J Nutr Date: 2021-07-30 Impact factor: 4.125