OBJECTIVE: To estimate the magnitude of the association between overweight, moderate, and extreme childhood obesity and the risk of idiopathic intracranial hypertension (IIH). STUDY DESIGN: Risk estimates were obtained from the Kaiser Permanente Southern California Children's Health Study (n = 913 178). Weight classes were assigned by body mass index specific for age and sex. A combination of electronic database searches followed by complete medical records review was used to identify all children diagnosed with IIH between 2006 and 2009. RESULTS: We identified 78 children with IIH, the majority of whom were girls (n = 66, 84.5%), age 11-19 (n = 66, 84.5%), non-Hispanic Whites (n = 37, 47.4%), and overweight or obese (n = 57, 73.1%). The adjusted ORs and 95% CIs of IIH with increasing weight class were 1.00, 3.56 (1.72-7.39), 6.45 (3.10-13.44), and 16.14 (8.18-31.85) for underweight/normal weight (reference category), overweight, moderately obese and extremely obese 11-19 year olds, respectively (P for trend < .001). Other independent IIH risk factors included White non-Hispanic race/ethnicity for all age groups and female sex, but only in older children. Overweight/obese children also had more IIH symptoms at onset than normal weight children. CONCLUSIONS: We found that childhood obesity is strongly associated with an increased risk of pediatric IIH in adolescents. Our findings suggest that the childhood obesity epidemic is likely to lead to increased morbidity from IIH particularly among extremely obese, White non-Hispanic teenage girls. Our findings also suggest careful screening of these at risk individuals may lead to earlier detection and opportunity for treatment of IIH.
OBJECTIVE: To estimate the magnitude of the association between overweight, moderate, and extreme childhood obesity and the risk of idiopathic intracranial hypertension (IIH). STUDY DESIGN: Risk estimates were obtained from the Kaiser Permanente Southern California Children's Health Study (n = 913 178). Weight classes were assigned by body mass index specific for age and sex. A combination of electronic database searches followed by complete medical records review was used to identify all children diagnosed with IIH between 2006 and 2009. RESULTS: We identified 78 children with IIH, the majority of whom were girls (n = 66, 84.5%), age 11-19 (n = 66, 84.5%), non-Hispanic Whites (n = 37, 47.4%), and overweight or obese (n = 57, 73.1%). The adjusted ORs and 95% CIs of IIH with increasing weight class were 1.00, 3.56 (1.72-7.39), 6.45 (3.10-13.44), and 16.14 (8.18-31.85) for underweight/normal weight (reference category), overweight, moderately obese and extremely obese 11-19 year olds, respectively (P for trend < .001). Other independent IIH risk factors included White non-Hispanic race/ethnicity for all age groups and female sex, but only in older children. Overweight/obesechildren also had more IIH symptoms at onset than normal weight children. CONCLUSIONS: We found that childhood obesity is strongly associated with an increased risk of pediatric IIH in adolescents. Our findings suggest that the childhood obesity epidemic is likely to lead to increased morbidity from IIH particularly among extremely obese, White non-Hispanic teenage girls. Our findings also suggest careful screening of these at risk individuals may lead to earlier detection and opportunity for treatment of IIH.
Authors: Corinna Koebnick; Karen J Coleman; Mary Helen Black; Ning Smith; Jack K Der-Sarkissian; Steven J Jacobsen; Amy H Porter Journal: Int J Epidemiol Date: 2011-01-20 Impact factor: 7.196
Authors: Robert J Kuczmarski; Cynthia L Ogden; Shumei S Guo; Laurence M Grummer-Strawn; Katherine M Flegal; Zuguo Mei; Rong Wei; Lester R Curtin; Alex F Roche; Clifford L Johnson Journal: Vital Health Stat 11 Date: 2002-05
Authors: Ning Smith; Rajan L Iyer; Annette Langer-Gould; Darios T Getahun; Daniel Strickland; Steven J Jacobsen; Wansu Chen; Stephen F Derose; Corinna Koebnick Journal: BMC Health Serv Res Date: 2010-11-23 Impact factor: 2.655
Authors: Claire A Sheldon; Grace L Paley; Shannon J Beres; Shana E McCormack; Grant T Liu Journal: Semin Pediatr Neurol Date: 2017-04-07 Impact factor: 1.636
Authors: Grace L Paley; Claire A Sheldon; Evanette K Burrows; Marianne R Chilutti; Grant T Liu; Shana E McCormack Journal: Am J Ophthalmol Date: 2014-11-07 Impact factor: 5.258
Authors: Claire A Sheldon; Grace L Paley; Rui Xiao; Anat Kesler; Ori Eyal; Melissa W Ko; Chantal J Boisvert; Robert A Avery; Vincenzo Salpietro; Paul H Phillips; Gena Heidary; Shana E McCormack; Grant T Liu Journal: Ophthalmology Date: 2016-09-28 Impact factor: 12.079
Authors: Janey S A Pratt; Allen Browne; Nancy T Browne; Matias Bruzoni; Megan Cohen; Ashish Desai; Thomas Inge; Bradley C Linden; Samer G Mattar; Marc Michalsky; David Podkameni; Kirk W Reichard; Fatima Cody Stanford; Meg H Zeller; Jeffrey Zitsman Journal: Surg Obes Relat Dis Date: 2018-03-23 Impact factor: 4.734