OBJECTIVE: To evaluate the association between serum P levels on the day of hCG administration and pregnancy outcome in women undergoing controlled ovarian hyperstimulation, prevention of premature ovulation by GnRH analogues, and fresh ET after 5 days of embryo culture. DESIGN: Retrospective, observational, cohort study. SETTING: Private IVF center. PATIENT(S): A total of 2,555 women undergoing fresh ET on day 5 in 2,062 GnRH agonist and 493 GnRH antagonist cycles. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live birth rate. RESULT(S): Live birth rate in cycles with GnRH agonists was significantly lower in women with P levels ≥ 2.0 ng/mL (17.4%) on the day of hCG administration as compared with women with P levels <1.5 ng/mL (24.6%) and 1.5-1.99 ng/mL (26.7%). No such significant differences in live birth rates in cycles with GnRH antagonist could be observed. CONCLUSION(S): A rise of serum P levels ≥ 2.0 ng/mL on the day of hCG administration is associated with impaired early embryo implantation and reduced live birth rate in cycles with GnRH agonists after day-5 fresh ET.
OBJECTIVE: To evaluate the association between serum P levels on the day of hCG administration and pregnancy outcome in women undergoing controlled ovarian hyperstimulation, prevention of premature ovulation by GnRH analogues, and fresh ET after 5 days of embryo culture. DESIGN: Retrospective, observational, cohort study. SETTING: Private IVF center. PATIENT(S): A total of 2,555 women undergoing fresh ET on day 5 in 2,062 GnRH agonist and 493 GnRH antagonist cycles. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live birth rate. RESULT(S): Live birth rate in cycles with GnRH agonists was significantly lower in women with P levels ≥ 2.0 ng/mL (17.4%) on the day of hCG administration as compared with women with P levels <1.5 ng/mL (24.6%) and 1.5-1.99 ng/mL (26.7%). No such significant differences in live birth rates in cycles with GnRH antagonist could be observed. CONCLUSION(S): A rise of serum P levels ≥ 2.0 ng/mL on the day of hCG administration is associated with impaired early embryo implantation and reduced live birth rate in cycles with GnRH agonists after day-5 fresh ET.
Authors: Matthew T Connell; Jennifer M Szatkowski; Nancy Terry; Alan H DeCherney; Anthony M Propst; Micah J Hill Journal: Fertil Steril Date: 2015-01-29 Impact factor: 7.329
Authors: Paula C Brady; Daniel J Kaser; Elizabeth S Ginsburg; Rachel K Ashby; Stacey A Missmer; Katharine F Correia; Catherine Racowsky Journal: J Assist Reprod Genet Date: 2014-03-12 Impact factor: 3.412
Authors: Julian A Gingold; Joseph A Lee; Jorge Rodriguez-Purata; Michael C Whitehouse; Benjamin Sandler; Lawrence Grunfeld; Tanmoy Mukherjee; Alan B Copperman Journal: Fertil Steril Date: 2015-06-13 Impact factor: 7.329