Literature DB >> 22631439

Can apolipoproteins and complement factors be biomarkers of Alzheimer's disease?

Pallavi Manral1, Pratibha Sharma, Gururao Hariprasad, Manjari Tripathi, Alagiri Srinivasan.   

Abstract

Alzheimer's disease is the most common cause of dementia in elderly persons. Quick diagnosis of Alzheimer's disease will allow treatments that may help slow its progression. The correlation between cerebrospinal fluid (CSF) parameters and progression of Alzheimer's disease is higher than and independent of other risk factors. We have compared sixteen CSF samples of clinically diagnosed Alzheimer's disease patients with non demented subjects using proteomics approach. Apolipoprotein E, apolipoprotein J, complement C4b, hemopexin and complement factor B were identified as differentially expressed proteins. Pathway analyses show that these proteins have interacting partners in Alzheimer's and apoptotic pathways. The possible roles of these proteins in relation to the disease are discussed.

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Year:  2012        PMID： 22631439     DOI： 10.2174/156720512803251110

Source DB:  PubMed          Journal:  Curr Alzheimer Res        ISSN： 1567-2050            Impact factor:   3.498


  8 in total

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Review 2.  Clinical proteomics of enervated neurons.

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Journal:  Arthritis Res Ther       Date:  2019-02-15       Impact factor: 5.156

4.  2D-DIGE as a strategy to identify serum protein biomarkers to monitor pharmacological efficacy in dopamine-dictated states of Parkinson's disease and schizophrenia.

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Journal:  Neuropsychiatr Dis Treat       Date:  2019-04-24       Impact factor: 2.570

5.  Evaluation of α-synuclein and apolipoprotein E as potential biomarkers in cerebrospinal fluid to monitor pharmacotherapeutic efficacy in dopamine dictated disease states of Parkinson's disease and schizophrenia.

Authors:  Ashish Kumar Gupta; Ruchika Pokhriyal; Uddipan Das; Mohd Imran Khan; Domada Ratna Kumar; Rishab Gupta; Rakesh Kumar Chadda; Rashmi Ramachandran; Vinay Goyal; Manjari Tripathi; Gururao Hariprasad
Journal:  Neuropsychiatr Dis Treat       Date:  2019-07-19       Impact factor: 2.570

6.  Cerebrospinal Fluid Proteomics For Identification Of α2-Macroglobulin As A Potential Biomarker To Monitor Pharmacological Therapeutic Efficacy In Dopamine Dictated Disease States Of Parkinson's Disease And Schizophrenia.

Authors:  Ashish Kumar Gupta; Ruchika Pokhriyal; Mohd Imran Khan; Domada Ratna Kumar; Rishab Gupta; Rakesh Kumar Chadda; Rashmi Ramachandran; Vinay Goyal; Manjari Tripathi; Gururao Hariprasad
Journal:  Neuropsychiatr Dis Treat       Date:  2019-10-02       Impact factor: 2.570

7.  Preoperative protein profiles in cerebrospinal fluid in elderly hip fracture patients at risk for delirium: A proteomics and validation study.

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Review 8.  A comprehensive systematic review of CSF proteins and peptides that define Alzheimer's disease.

Authors:  Juan R Peinado; Yoana Rabanal-Ruiz; Cristina M Pedrero-Prieto; Sonia García-Carpintero; Javier Frontiñán-Rubio; Emilio Llanos-González; Cristina Aguilera García; Francisco J Alcaín; Iris Lindberg; Mario Durán-Prado
Journal:  Clin Proteomics       Date:  2020-06-05       Impact factor: 3.988
  8 in total

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