| Literature DB >> 22630342 |
Julie Risse1, Mariano A Fernández-Zúmel, Yanouk Cudré, Kay Severin.
Abstract
A two-step process for the synthesis of trifluoromethyl-substituted cyclopropanes is described. Halothane, an anesthetic agent, is added to olefins in a ruthenium-catalyzed Kharasch reaction. The resulting 1,3-dihalides are converted into cyclopropanes by dehalogenation with magnesium. This procedure represents an alternative to metal-catalyzed cyclopropanations involving trifluoromethyl diazomethane.Entities:
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Year: 2012 PMID： 22630342 DOI： 10.1021/ol3011369
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005