BACKGROUND: Reference intervals are crucial decision-making tools aiding clinicians in differentiating between healthy and diseased populations. However, for children such values often are lacking or incomplete. METHODS: Blood samples were obtained from 692 healthy children, aged 6 months to 18 years, recruited in daycare centers and schools. Twelve common general clinical chemistry analytes were measured on the Abbott Architect ci8200 platform; sodium, potassium, chloride, calcium, albumin-adjusted calcium, phosphate, magnesium, creatinine (Jaffe and enzymatic), cystatin C, urea and uric acid. RESULTS: Age- and gender specific pediatric reference intervals were defined by calculating the 2.5th and 97.5th percentiles. CONCLUSIONS: The data generated is primarily applicable to a Caucasian population when using the Abbott Architect platform, but could be used by any laboratory if validated for the local patient population.
BACKGROUND: Reference intervals are crucial decision-making tools aiding clinicians in differentiating between healthy and diseased populations. However, for children such values often are lacking or incomplete. METHODS: Blood samples were obtained from 692 healthy children, aged 6 months to 18 years, recruited in daycare centers and schools. Twelve common general clinical chemistry analytes were measured on the Abbott Architect ci8200 platform; sodium, potassium, chloride, calcium, albumin-adjusted calcium, phosphate, magnesium, creatinine (Jaffe and enzymatic), cystatin C, urea and uric acid. RESULTS: Age- and gender specific pediatric reference intervals were defined by calculating the 2.5th and 97.5th percentiles. CONCLUSIONS: The data generated is primarily applicable to a Caucasian population when using the Abbott Architect platform, but could be used by any laboratory if validated for the local patient population.
Authors: Kyle E Rodenbach; Michael F Schneider; Susan L Furth; Marva M Moxey-Mims; Mark M Mitsnefes; Donald J Weaver; Bradley A Warady; George J Schwartz Journal: Am J Kidney Dis Date: 2015-07-21 Impact factor: 8.860
Authors: Daniel E Roth; Alison D Gernand; Shaun K Morris; Brendon Pezzack; M Munirul Islam; Michelle C Dimitris; Shaila S Shanta; Stanley H Zlotkin; Andrew R Willan; Tahmeed Ahmed; Prakesh S Shah; Kellie E Murphy; Rosanna Weksberg; Sanaa Choufani; Rashed Shah; Abdullah Al Mahmud Journal: Trials Date: 2015-07-14 Impact factor: 2.279