| Literature DB >> 22628223 |
Dashzeveg Bayarsaihan1, Aleksandr V Makeyev, Badam Enkhmandakh.
Abstract
TFII-I transcription factors play an essential role during early vertebrate embryogenesis. Genome-wide mapping studies by ChIP-seq and ChIP-chip revealed that TFII-I primes multiple genomic loci in mouse embryonic stem cells and embryonic tissues. Moreover, many TFII-I-bound regions co-localize with H3K4me3/K27me3 bivalent chromatin within the promoters of lineage-specific genes. This minireview provides a summary of current knowledge regarding the function of TFII-I in epigenetic control of stem cell differentiation.Entities:
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Year: 2012 PMID: 22628223 DOI: 10.1002/jcb.24202
Source DB: PubMed Journal: J Cell Biochem ISSN: 0730-2312 Impact factor: 4.429