PURPOSE: To determine if small hard drusen in patients with basal laminar drusen show short-term changes. DESIGN: Prospective observational case series. METHODS: Ten subjects with basal laminar drusen were longitudinally followed during a period of 4 months by spectral-domain optical coherence tomography. Drusen that showed a spontaneous change in volume were further analyzed according to 5 morphologic parameters: shape, reflectivity, homogeneity, and concurring photoreceptor layer/retinal pigment epithelium damage. Odds ratios (OR) and risk for regression and progression of drusen volumes were calculated. RESULTS: One hundred and five small hard drusen in 19 eyes showed a spontaneous change in volume over the period of follow-up. Drusen with a "pointed" shape were significantly associated (P = .031; OR 4.89; 95% confidence interval [CI] 1.16-20.67) with spontaneous progression in drusen volume, with a chance of 0.80 (95% CI 0.55-0.93) to progress. Drusen that showed a decreased reflectivity of overlying photoreceptor layer (P = .041; OR 7.67; 95% CI 1.09-54.24) or retinal pigment epithelium (P = .022; OR 12.38; 95% CI 1.44-106.57), showed a significant association with spontaneous regression in drusen volume, with chances of regression of 0.86 (95% CI 0.41-0.98) and 0.89 (95% CI 0.49-0.99), respectively. CONCLUSION: Small hard drusen in patients with the basal laminar drusen phenotype are subject to a process of short-term remodeling. The dynamic nature of this disease points to high biochemical activity that may be sensitive to future pharmacologic treatment strategies. In addition, these short-term changes of drusen may be a source of misclassification in disease staging.
PURPOSE: To determine if small hard drusen in patients with basal laminar drusen show short-term changes. DESIGN: Prospective observational case series. METHODS: Ten subjects with basal laminar drusen were longitudinally followed during a period of 4 months by spectral-domain optical coherence tomography. Drusen that showed a spontaneous change in volume were further analyzed according to 5 morphologic parameters: shape, reflectivity, homogeneity, and concurring photoreceptor layer/retinal pigment epithelium damage. Odds ratios (OR) and risk for regression and progression of drusen volumes were calculated. RESULTS: One hundred and five small hard drusen in 19 eyes showed a spontaneous change in volume over the period of follow-up. Drusen with a "pointed" shape were significantly associated (P = .031; OR 4.89; 95% confidence interval [CI] 1.16-20.67) with spontaneous progression in drusen volume, with a chance of 0.80 (95% CI 0.55-0.93) to progress. Drusen that showed a decreased reflectivity of overlying photoreceptor layer (P = .041; OR 7.67; 95% CI 1.09-54.24) or retinal pigment epithelium (P = .022; OR 12.38; 95% CI 1.44-106.57), showed a significant association with spontaneous regression in drusen volume, with chances of regression of 0.86 (95% CI 0.41-0.98) and 0.89 (95% CI 0.49-0.99), respectively. CONCLUSION: Small hard drusen in patients with the basal laminar drusen phenotype are subject to a process of short-term remodeling. The dynamic nature of this disease points to high biochemical activity that may be sensitive to future pharmacologic treatment strategies. In addition, these short-term changes of drusen may be a source of misclassification in disease staging.
Authors: Brian C Toy; Nupura Krishnadev; Maanasa Indaram; Denise Cunningham; Catherine A Cukras; Emily Y Chew; Wai T Wong Journal: Am J Ophthalmol Date: 2013-07-03 Impact factor: 5.258
Authors: Guorong Li; Sina Farsiu; Jianming Qiu; Angela Dixon; Chunwei Song; Stuart J McKinnon; Fan Yuan; Pedro Gonzalez; W Daniel Stamer Journal: Mol Vis Date: 2014-12-20 Impact factor: 2.367
Authors: Maheswara R Duvvari; Johannes P H van de Ven; Maartje J Geerlings; Nicole T M Saksens; Bjorn Bakker; Arjen Henkes; Kornelia Neveling; Marisol del Rosario; Dineke Westra; Lambertus P W J van den Heuvel; Tina Schick; Sascha Fauser; Camiel J F Boon; Carel B Hoyng; Eiko K de Jong; Anneke I den Hollander Journal: PLoS One Date: 2016-03-23 Impact factor: 3.240