Chemo-enzymatic conversion of glucose into 5-hydroxymethylfurfural in seawater.

Do you sea water? Water consumption will be a challenge in biorefineries, and the use of non-drinkable sources of water will be preferred. Herein, glucose is converted into 5-hydroxymethylfurfural (HMF) in a chemo-enzymatic one-pot, two-step procedure, involving immobilized glucose isomerase to produce fructose and oxalic acid to dehydrate it to HMF.