Literature DB >> 22623180

Novel treatments for NEC: keeping IBD in mind.

Sanjiv Harpavat1, Mohan Pammi, Mark Gilger.   

Abstract

Necrotizing enterocolitis (NEC) is an inflammatory intestinal disease of premature newborns, thought to result in part from overactivity of the innate immune system. NEC has been well-studied from the perspective of prevention; however, after the disease onset, there are limited treatment options to control its progression. This review discusses four potential therapies that target the overactive immune response in NEC: pentoxifylline, platelet activating factor modulators, glucocorticoids, and vasoactive substances. In addition, given the similar pathogenesis of NEC and inflammatory bowel disease (IBD), we propose that IBD therapies could provide promising leads for novel strategies with which to treat NEC.

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Year:  2012        PMID： 22623180     DOI： 10.1007/s11894-012-0267-3

Source DB:  PubMed          Journal:  Curr Gastroenterol Rep        ISSN： 1522-8037


  66 in total

1.  Acute necrotizing enterocolitis in infancy: a review of 64 cases.

Authors:  T V Sántulli; J N Schullinger; W C Heird; R D Gongaware; J Wigger; B Barlow; W A Blanc; W E Berdon
Journal:  Pediatrics       Date:  1975-03       Impact factor: 7.124

2.  Production of proinflammatory cytokines and cytokines involved in the TH1/TH2 balance is modulated by pentoxifylline.

Authors:  J Bienvenu; C Doche; M C Gutowski; M Lenoble; A Lepape; J P Perdrix
Journal:  J Cardiovasc Pharmacol       Date:  1995       Impact factor: 3.105

3.  Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates.

Authors:  Alona Bin-Nun; Ruben Bromiker; Michael Wilschanski; Michael Kaplan; Bernard Rudensky; Michael Caplan; Cathy Hammerman
Journal:  J Pediatr       Date:  2005-08       Impact factor: 4.406

Review 4.  Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa.

Authors:  Nita H Salzman; Mark A Underwood; Charles L Bevins
Journal:  Semin Immunol       Date:  2007-05-07       Impact factor: 11.130

5.  Amelioration of ischemia-reperfusion injury in rat intestine by pentoxifylline-mediated inhibition of xanthine oxidase.

Authors:  C Hammerman; D Goldschmidt; M S Caplan; M Kaplan; M S Schimmel; A I Eidelman; D Branski; A Hochman
Journal:  J Pediatr Gastroenterol Nutr       Date:  1999-07       Impact factor: 2.839

6.  Endothelin-1 in human intestine resected for necrotizing enterocolitis.

Authors:  Philip T Nowicki; David J Dunaway; Craig A Nankervis; Peter J Giannone; Peter J Giannnone; Kristina M Reber; Susan B Hammond; Gail E Besner; Donna A Caniano
Journal:  J Pediatr       Date:  2005-06       Impact factor: 4.406

7.  Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors.

Authors:  Erika C Claud; Tor Savidge; W Allen Walker
Journal:  Pediatr Res       Date:  2003-03       Impact factor: 3.756

8.  Pentoxifylline reduces the incidence and severity of necrotizing enterocolitis in a neonatal rat model.

Authors:  Javeed Travadi; Sanjay Patole; Adrian Charles; Bohuslav Dvorak; Dorota Doherty; Karen Simmer
Journal:  Pediatr Res       Date:  2006-08       Impact factor: 3.756

9.  High morbidity of enterostomy and its closure in premature infants with necrotizing enterocolitis.

Authors:  A O'Connor; R S Sawin
Journal:  Arch Surg       Date:  1998-08

10.  A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair.

Authors:  Cynthia L Leaphart; Jaime Cavallo; Steven C Gribar; Selma Cetin; Jun Li; Maria F Branca; Theresa D Dubowski; Chhinder P Sodhi; David J Hackam
Journal:  J Immunol       Date:  2007-10-01       Impact factor: 5.422
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  5 in total

1.  Berberine reduces the occurrence of neonatal necrotizing enterocolitis by reducing the inflammatory response.

Authors:  Yong Jing; Fudong Peng; Yufeng Shan; Jingkai Jiang
Journal:  Exp Ther Med       Date:  2018-10-17       Impact factor: 2.447

Review 2.  Animal models for studying epithelial barriers in neonatal necrotizing enterocolitis, inflammatory bowel disease and colorectal cancer.

Authors:  Tiaosi Xing; Rolando Camacho Salazar; Yan-Hua Chen
Journal:  Tissue Barriers       Date:  2017-08-10

3.  Fecal amine metabolite analysis before onset of severe necrotizing enterocolitis in preterm infants: a prospective case-control study.

Authors:  N Deianova; S El Manouni El Hassani; E A Struijs; E E W Jansen; A Bakkali; M A van de Wiel; W P de Boode; C V Hulzebos; A H van Kaam; B W Kramer; E d'Haens; D C Vijlbrief; M M van Weissenbruch; W J de Jonge; M A Benninga; H J Niemarkt; N K H de Boer; T G J de Meij
Journal:  Sci Rep       Date:  2022-07-19       Impact factor: 4.996

4.  Sulforaphane Ameliorates the Intestinal Injury in Necrotizing Enterocolitis by Regulating the PI3K/Akt/GSK-3β Signaling Pathway.

Authors:  Zhong-Kun Bao; Yan-Hong Mi; Xiao-Yu Xiong; Xin-Hong Wang
Journal:  Can J Gastroenterol Hepatol       Date:  2022-05-11

5.  Dextran sodium sulfate (DSS) induces necrotizing enterocolitis-like lesions in neonatal mice.

Authors:  Marco Ginzel; Xiaoyan Feng; Joachim F Kuebler; Christian Klemann; Yi Yu; Reinhard von Wasielewski; Joon-Keun Park; Mathias W Hornef; Gertrud Vieten; Benno M Ure; Torsten Kaussen; Jan Hendrik Gosemann; Steffi Mayer; Anne Suttkus; Martin Lacher
Journal:  PLoS One       Date:  2017-08-17       Impact factor: 3.240
  5 in total

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