Literature DB >> 22620495

Critical analysis of treatment trials of rhesus macaques infected with Borrelia burgdorferi reveals important flaws in experimental design.

Gary P Wormser1, Phillip J Baker, Susan O'Connell, Andrew R Pachner, Ira Schwartz, Eugene D Shapiro.   

Abstract

A critical analysis of two treatment trials of Chinese rhesus macaques infected with Borrelia burgdorferi indicates that insufficient attention was placed on documenting the blood levels, pharmacokinetics, and pharmacodynamic parameters of the antibiotics used in this host. Consequently, it is impossible to conclude that the findings have validity in judging the efficacy of doxycycline or ceftriaxone for the treatment of Borrelia burgdorferi in this animal model.

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Year:  2012        PMID： 22620495      PMCID： PMC3398392          DOI： 10.1089/vbz.2012.1012

Source DB:  PubMed          Journal:  Vector Borne Zoonotic Dis        ISSN： 1530-3667            Impact factor:   2.133


  22 in total

1.  Effect of post-treatment holding conditions on detection of tufA mRNA in ethanol-treated Escherichia coli: implications for RT-PCR-based indirect viability tests.

Authors:  G E Sheridan; E A Szabo; B M Mackey
Journal:  Lett Appl Microbiol       Date:  1999-12       Impact factor: 2.858

Review 2.  A matter of bacterial life and death.

Authors:  G Bogosian; E V Bourneuf
Journal:  EMBO Rep       Date:  2001-09       Impact factor: 8.807

3.  A comparison of nucleic acid amplification techniques for the assessment of bacterial viability.

Authors:  L Birch; C E Dawson; J H Cornett; J T Keer
Journal:  Lett Appl Microbiol       Date:  2001-10       Impact factor: 2.858

4.  Comparative pharmacokinetics of YM-13115, ceftriaxone, and ceftazidime in rats, dogs, and rhesus monkeys.

Authors:  H Matsui; M Komiya; C Ikeda; A Tachibana
Journal:  Antimicrob Agents Chemother       Date:  1984-08       Impact factor: 5.191

5.  Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease.

Authors:  M S Klempner; L T Hu; J Evans; C H Schmid; G M Johnson; R P Trevino; D Norton; L Levy; D Wall; J McCall; M Kosinski; A Weinstein
Journal:  N Engl J Med       Date:  2001-07-12       Impact factor: 91.245

6.  Long-term follow-up of patients with culture-confirmed Lyme disease.

Authors:  John Nowakowski; Robert B Nadelman; Rebecca Sell; Donna McKenna; L Frank Cavaliere; Diane Holmgren; Adriana Gaidici; Gary P Wormser
Journal:  Am J Med       Date:  2003-08-01       Impact factor: 4.965

Review 7.  Pharmacokinetic profile of ceftriaxone in man.

Authors:  I H Patel; S A Kaplan
Journal:  Am J Med       Date:  1984-10-19       Impact factor: 4.965

8.  Relationship of messenger RNA reverse transcriptase-polymerase chain reaction signal to Campylobacter spp. viability.

Authors:  K D Sung; N J Stern; K L Hiett
Journal:  Avian Dis       Date:  2004 Apr-Jun       Impact factor: 1.577

Review 9.  Controlled trials of antibiotic treatment in patients with post-treatment chronic Lyme disease.

Authors:  Mark S Klempner
Journal:  Vector Borne Zoonotic Dis       Date:  2002       Impact factor: 2.133

10.  Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection.

Authors:  Monica E Embers; Stephen W Barthold; Juan T Borda; Lisa Bowers; Lara Doyle; Emir Hodzic; Mary B Jacobs; Nicole R Hasenkampf; Dale S Martin; Sukanya Narasimhan; Kathrine M Phillippi-Falkenstein; Jeanette E Purcell; Marion S Ratterree; Mario T Philipp
Journal:  PLoS One       Date:  2012-01-11       Impact factor: 3.240
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  9 in total

1.  Xenodiagnosis for posttreatment Lyme disease syndrome: resolving the conundrum or adding to it?

Authors:  Linda K Bockenstedt; Justin D Radolf
Journal:  Clin Infect Dis       Date:  2014-02-11       Impact factor: 9.079

Review 2.  Sleeper cells: the stringent response and persistence in the Borreliella (Borrelia) burgdorferi enzootic cycle.

Authors:  Felipe C Cabello; Henry P Godfrey; Julia V Bugrysheva; Stuart A Newman
Journal:  Environ Microbiol       Date:  2017-09-11       Impact factor: 5.491

3.  Xenodiagnosis to detect Borrelia burgdorferi infection: a first-in-human study.

Authors:  Adriana Marques; Sam R Telford; Siu-Ping Turk; Erin Chung; Carla Williams; Kenneth Dardick; Peter J Krause; Christina Brandeburg; Christopher D Crowder; Heather E Carolan; Mark W Eshoo; Pamela A Shaw; Linden T Hu
Journal:  Clin Infect Dis       Date:  2014-02-11       Impact factor: 9.079

4.  Detection of Borrelia burgdorferi nucleic acids after antibiotic treatment does not confirm viability.

Authors:  Radha Iyer; Priyanka Mukherjee; Kemeng Wang; Joshua Simons; Gary P Wormser; Ira Schwartz
Journal:  J Clin Microbiol       Date:  2012-12-26       Impact factor: 5.948

5.  Nervous system lyme disease: diagnosis and treatment.

Authors:  John J Halperin
Journal:  Curr Treat Options Neurol       Date:  2013-08       Impact factor: 3.598

6.  Critical analysis of a doxycycline treatment trial of rhesus macaques infected with Borrelia burgdorferi.

Authors:  Gary P Wormser; Susan O'Connell; Andrew R Pachner; Ira Schwartz; Eugene D Shapiro; Gerold Stanek; Franc Strle
Journal:  Diagn Microbiol Infect Dis       Date:  2018-06-18       Impact factor: 2.803

Review 7.  Borreliella burgdorferi Antimicrobial-Tolerant Persistence in Lyme Disease and Posttreatment Lyme Disease Syndromes.

Authors:  Felipe C Cabello; Monica E Embers; Stuart A Newman; Henry P Godfrey
Journal:  mBio       Date:  2022-04-25       Impact factor: 7.786

8.  Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library.

Authors:  Jie Feng; Ting Wang; Wanliang Shi; Shuo Zhang; David Sullivan; Paul G Auwaerter; Ying Zhang
Journal:  Emerg Microbes Infect       Date:  2014-07-02       Impact factor: 7.163

Review 9.  Recent Progress in Lyme Disease and Remaining Challenges.

Authors:  Jason R Bobe; Brandon L Jutras; Elizabeth J Horn; Monica E Embers; Allison Bailey; Robert L Moritz; Ying Zhang; Mark J Soloski; Richard S Ostfeld; Richard T Marconi; John Aucott; Avi Ma'ayan; Felicia Keesing; Kim Lewis; Choukri Ben Mamoun; Alison W Rebman; Mecaila E McClune; Edward B Breitschwerdt; Panga Jaipal Reddy; Ricardo Maggi; Frank Yang; Bennett Nemser; Aydogan Ozcan; Omai Garner; Dino Di Carlo; Zachary Ballard; Hyou-Arm Joung; Albert Garcia-Romeu; Roland R Griffiths; Nicole Baumgarth; Brian A Fallon
Journal:  Front Med (Lausanne)       Date:  2021-08-18
  9 in total

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