Literature DB >> 226198

Cholesterol synthesis by human fibroblasts in the presence of LDL and anti-LDL IgA.

C Dachet, M F Baudet, J L Beaumont.   

Abstract

LDL interact with fibroblasts through specific membrane sites. This reaction is the first step of a mechanism which leads to the regulation of intracellular cholesterol synthesis. When LDL form a complex with an IgA from a myeloma serum with mixed hyperlipidemia and xanthomatosis, they no longer function as a regulator, and the result is excess production of free intracellular cholesterol. No excess cholesterol production is observed when myeloma IgA is replaced by control IgG and IgA.

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Year:  1979        PMID： 226198

Source DB:  PubMed          Journal:  Biomedicine        ISSN： 0300-0893


  4 in total

1.  Immune complex hyperlipidemia induced by an apolipoprotein-reactive immunoglobulin A paraprotein from a patient with multiple myeloma. Characterization of this immunoglobulin.

Authors:  L L Kilgore; B W Patterson; D M Parenti; W R Fisher
Journal:  J Clin Invest       Date:  1985-07       Impact factor: 14.808

Review 2.  Atherosclerosis and antiphospholipid syndrome.

Authors:  Luis J Jara; Gabriela Medina; Olga Vera-Lastra; Yehuda Shoenfeld
Journal:  Clin Rev Allergy Immunol       Date:  2003-08       Impact factor: 8.667

3.  Interaction between fibroblasts, lipoproteins and three antilipoproteins IgA kappa.

Authors:  M F Baudet; C Dachet; J L Beaumont
Journal:  Clin Exp Immunol       Date:  1980-02       Impact factor: 4.330

Review 4.  Low density lipoprotein-containing circulating immune complexes: role in atherosclerosis and diagnostic value.

Authors:  Igor A Sobenin; Jukka T Salonen; Andrey V Zhelankin; Alexandra A Melnichenko; Jari Kaikkonen; Yuri V Bobryshev; Alexander N Orekhov
Journal:  Biomed Res Int       Date:  2014-06-18       Impact factor: 3.411
  4 in total

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