Literature DB >> 22619643

Should Postmastectomy Radiotherapy to the Chest Wall and Regional Lymph Nodes Be Standard for Patients with 1-3 Positive Lymph Nodes?

Birgitte V Offersen1, Hans-Jürgen Brodersen, Mette M Nielsen, Jens Overgaard, Marie Overgaard.   

Abstract

The indication for adjuvant postmastectomy radiotherapy (PMRT) in breast cancer patients with small tumors and 1-3 macrometastases in the axilla remains a controversial issue, despite the recommendation that PMRT should be applied in these patients in the most recent overview by the Early Breast Cancer Trialists' Collaborative Group. In this report, we discuss the available data on the benefit from PMRT in patients diagnosed with N1 breast cancer. Based on this, we recommend adjuvant PMRT to the chest wall and regional lymph nodes in patients diagnosed with early node-positive breast cancer.

Entities:  

Year:  2011        PMID： 22619643      PMCID： PMC3357155          DOI： 10.1159/000333250

Source DB:  PubMed          Journal:  Breast Care (Basel)        ISSN： 1661-3791            Impact factor:   2.860


  26 in total

1.  The curative role of radiotherapy in the treatment of operable breast cancer.

Authors:  J Kurtz
Journal:  Eur J Cancer       Date:  2002-10       Impact factor: 9.162

Review 2.  Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials.

Authors:  M Clarke; R Collins; S Darby; C Davies; P Elphinstone; V Evans; J Godwin; R Gray; C Hicks; S James; E MacKinnon; P McGale; T McHugh; R Peto; C Taylor; Y Wang
Journal:  Lancet       Date:  2005-12-17       Impact factor: 79.321

3.  Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer.

Authors:  J Ragaz; S M Jackson; N Le; I H Plenderleith; J J Spinelli; V E Basco; K S Wilson; M A Knowling; C M Coppin; M Paradis; A J Coldman; I A Olivotto
Journal:  N Engl J Med       Date:  1997-10-02       Impact factor: 91.245

4.  Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial.

Authors:  Joseph Ragaz; Ivo A Olivotto; John J Spinelli; Norman Phillips; Stewart M Jackson; Kenneth S Wilson; Margaret A Knowling; Christopher M L Coppin; Lorna Weir; Karen Gelmon; Nhu Le; Ralph Durand; Andrew J Coldman; Mohamed Manji
Journal:  J Natl Cancer Inst       Date:  2005-01-19       Impact factor: 13.506

5.  Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial.

Authors:  M Overgaard; M B Jensen; J Overgaard; P S Hansen; C Rose; M Andersson; C Kamby; M Kjaer; C C Gadeberg; B B Rasmussen; M Blichert-Toft; H T Mouridsen
Journal:  Lancet       Date:  1999-05-15       Impact factor: 79.321

6.  Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial.

Authors:  M Overgaard; P S Hansen; J Overgaard; C Rose; M Andersson; F Bach; M Kjaer; C C Gadeberg; H T Mouridsen; M B Jensen; K Zedeler
Journal:  N Engl J Med       Date:  1997-10-02       Impact factor: 91.245

7.  Study of failure pattern among high-risk breast cancer patients with or without postmastectomy radiotherapy in addition to adjuvant systemic therapy: long-term results from the Danish Breast Cancer Cooperative Group DBCG 82 b and c randomized studies.

Authors:  Hanne M Nielsen; Marie Overgaard; Cai Grau; Anni R Jensen; Jens Overgaard
Journal:  J Clin Oncol       Date:  2006-04-17       Impact factor: 44.544

8.  Estrogen receptor, progesterone receptor, HER-2, and response to postmastectomy radiotherapy in high-risk breast cancer: the Danish Breast Cancer Cooperative Group.

Authors:  Marianne Kyndi; Flemming B Sørensen; Helle Knudsen; Marie Overgaard; Hanne Melgaard Nielsen; Jens Overgaard
Journal:  J Clin Oncol       Date:  2008-02-19       Impact factor: 44.544

9.  Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden.

Authors:  Paul McGale; Sarah C Darby; Per Hall; Jan Adolfsson; Nils-Olof Bengtsson; Anna M Bennet; Tommy Fornander; Bruna Gigante; Maj-Britt Jensen; Richard Peto; Kazem Rahimi; Carolyn W Taylor; Marianne Ewertz
Journal:  Radiother Oncol       Date:  2011-08       Impact factor: 6.280

10.  Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009.

Authors:  A Goldhirsch; J N Ingle; R D Gelber; A S Coates; B Thürlimann; H-J Senn
Journal:  Ann Oncol       Date:  2009-06-17       Impact factor: 32.976
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  3 in total

1.  The Challenge of Integrating Radiotherapy in the Multimodal Treatment of Breast Cancer.

Authors:  Rainer Souchon; Juergen Dunst
Journal:  Breast Care (Basel)       Date:  2011-10-31       Impact factor: 2.860

2.  DEGRO practical guidelines for radiotherapy of breast cancer IV: radiotherapy following mastectomy for invasive breast cancer.

Authors:  Frederik Wenz; Elena Sperk; Wilfried Budach; Jürgen Dunst; Petra Feyer; Rainer Fietkau; Wulf Haase; Wolfgang Harms; Marc D Piroth; Marie-Luise Sautter-Bihl; Felix Sedlmayer; Rainer Souchon; Christoph Fussl; Rolf Sauer
Journal:  Strahlenther Onkol       Date:  2014-08       Impact factor: 3.621

3.  Postmastectomy radiotherapy improves disease-free survival of high risk of locoregional recurrence breast cancer patients with T1-2 and 1 to 3 positive nodes.

Authors:  Zhen-Yu He; San-Gang Wu; Juan Zhou; Fang-Yan Li; Qin Lin; Huan-Xin Lin; Jia-Yuan Sun
Journal:  PLoS One       Date:  2015-03-17       Impact factor: 3.240
  3 in total

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