OBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis. METHOD: Sixty-six patients with medically refractory TLE with unilateral MTS after anterior temporal lobectomy were included. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patient's clinical data and surgical outcome were reviewed. RESULTS: Occurrence of initial precipitating insult (IPI), as well as better postoperative seizure control (i.e. Engel class 1), were associated with classical and severe patterns of hippocampal sclerosis (MTS type 1a and 1b, respectively). CONCLUSION: Quantitative evaluation of hippocampal neuronal loss patterns predicts surgical outcome in patients with TLE-MTS.
OBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis. METHOD: Sixty-six patients with medically refractory TLE with unilateral MTS after anterior temporal lobectomy were included. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patient's clinical data and surgical outcome were reviewed. RESULTS: Occurrence of initial precipitating insult (IPI), as well as better postoperative seizure control (i.e. Engel class 1), were associated with classical and severe patterns of hippocampal sclerosis (MTS type 1a and 1b, respectively). CONCLUSION: Quantitative evaluation of hippocampal neuronal loss patterns predicts surgical outcome in patients with TLE-MTS.
Authors: Maged Goubran; Boris C Bernhardt; Diego Cantor-Rivera; Jonathan C Lau; Charlotte Blinston; Robert R Hammond; Sandrine de Ribaupierre; Jorge G Burneo; Seyed M Mirsattari; David A Steven; Andrew G Parrent; Andrea Bernasconi; Neda Bernasconi; Terry M Peters; Ali R Khan Journal: Hum Brain Mapp Date: 2015-12-17 Impact factor: 5.038
Authors: G A Martínez-Levy; L Rocha; F Rodríguez-Pineda; M A Alonso-Vanegas; A Nani; R M Buentello-García; M Briones-Velasco; D San-Juan; J Cienfuegos; C S Cruz-Fuentes Journal: Mol Neurobiol Date: 2017-05-19 Impact factor: 5.590
Authors: Sarah Treit; Graham Little; Trevor Steve; Tom Nowacki; Laura Schmitt; B Matt Wheatley; Christian Beaulieu; Donald W Gross Journal: Epilepsia Open Date: 2019-09-13