Histological pattern of testicular biopsies in infertile males in Ibadan, Nigeria.

Testicular biopsies available in the records of the Pathology Department of the University College Hospital, Ibadan were reviewed to determine the histological pattern of primary testicular failure in this environment. Of the available biopsies, 152 were found to be adequate for study. Fifty-eight cases (38.2%) had normal spermatogenetic activity. Thirty-four cases (22.4%) had extensive or marked diffuse tubular atrophy associated with peritubular hyalinization and interstitial fibrosis. It is suggested that previous inflammatory process may play a major role in the causation of primary testicular failure in the environment.