| Literature DB >> 22618302 |
Se Hee Kim1, Hye Rim Chung, Seung Hyo Kim, Hunmin Kim, Byung Chan Lim, Jong Hee Chae, Ki Joong Kim, Yong Seung Hwang, Hee Hwang.
Abstract
The aim of this study was to evaluate the incidence of thyroid dysfunction during valproic acid (VPA) therapy in children and adolescents with epilepsy. The serum levels of thyroid-stimulating hormone (TSH), free thyroxine, and triiodothyronine were evaluated in 61 children with epilepsy who received VPA monotherapy for more than 6 months and in 144 controls. We analyzed the effect of age, seizure type, duration of VPA treatment, dose of VPA, and serum level of VPA on thyroid function. The incidence of subclinical hypothyroidism was significantly higher in patients with VPA therapy than in controls (52.4 vs. 16.7%; p < 0.001). In addition, of the 61 patients, 5 (8.1%) exhibited TSH levels that were >10 μIU/mL. However, none of the patients and controls showed overt hypothyroidism. Serum VPA level and daily dose of VPA were correlated with TSH level. Subclinical hypothyroidism developed frequently in children and adolescents during VPA therapy. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Entities:
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Year: 2012 PMID： 22618302 DOI： 10.1055/s-0032-1313913
Source DB: PubMed Journal: Neuropediatrics ISSN： 0174-304X Impact factor: 1.947