Literature DB >> 22618082

Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM1 gangliosidosis.

M Aguilar-Moncayo1, T Takai, K Higaki, T Mena-Barragán, Y Hirano, K Yura, L Li, Y Yu, H Ninomiya, M I García-Moreno, S Ishii, Y Sakakibara, K Ohno, E Nanba, C Ortiz Mellet, J M García Fernández, Y Suzuki.   

Abstract

Competitive inhibitors of either α-galactosidase (α-Gal) or β-galactosidase (β-Gal) with high affinity and selectivity have been accessed by exploiting aglycone interactions with conformationally locked sp(2)-iminosugars. Selected compounds were profiled as potent pharmacological chaperones for mutant lysosomal α- and β-Gal associated with Fabry disease and GM(1) gangliosidosis.

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Year:  2012        PMID： 22618082     DOI： 10.1039/c2cc32065g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  Synthesis of a New β-Galactosidase Inhibitor Displaying Pharmacological Chaperone Properties for GM1 Gangliosidosis.

Authors:  Francesca Clemente; Macarena Martínez-Bailén; Camilla Matassini; Amelia Morrone; Silvia Falliano; Anna Caciotti; Paolo Paoli; Andrea Goti; Francesca Cardona
Journal:  Molecules       Date:  2022-06-22       Impact factor: 4.927

2.  A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.

Authors:  Tomoko Takai; Katsumi Higaki; Matilde Aguilar-Moncayo; Teresa Mena-Barragán; Yuki Hirano; Kei Yura; Liang Yu; Haruaki Ninomiya; M Isabel García-Moreno; Yasubumi Sakakibara; Kousaku Ohno; Eiji Nanba; Carmen Ortiz Mellet; José M García Fernández; Yoshiyuki Suzuki
Journal:  Mol Ther       Date:  2013-01-22       Impact factor: 11.454

3.  Structural basis of pharmacological chaperoning for human β-galactosidase.

Authors:  Hironori Suzuki; Umeharu Ohto; Katsumi Higaki; Teresa Mena-Barragán; Matilde Aguilar-Moncayo; Carmen Ortiz Mellet; Eiji Nanba; Jose M Garcia Fernandez; Yoshiyuki Suzuki; Toshiyuki Shimizu
Journal:  J Biol Chem       Date:  2014-04-15       Impact factor: 5.157

4.  New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells.

Authors:  Ghada Allan; Halima Ouadid-Ahidouch; Elena M Sanchez-Fernandez; Rocío Risquez-Cuadro; José M Garcia Fernandez; Carmen Ortiz-Mellet; Ahmed Ahidouch
Journal:  PLoS One       Date:  2013-10-04       Impact factor: 3.240

5.  Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease.

Authors:  Mario de la Mata; David Cotán; Manuel Oropesa-Ávila; Juan Garrido-Maraver; Mario D Cordero; Marina Villanueva Paz; Ana Delgado Pavón; Elizabet Alcocer-Gómez; Isabel de Lavera; Patricia Ybot-González; Ana Paula Zaderenko; Carmen Ortiz Mellet; José M García Fernández; José A Sánchez-Alcázar
Journal:  Sci Rep       Date:  2015-06-05       Impact factor: 4.379

6.  Fast urinary screening of oligosaccharidoses by MALDI-TOF/TOF mass spectrometry.

Authors:  Laurent Bonesso; Monique Piraud; Céline Caruba; Emmanuel Van Obberghen; Raymond Mengual; Charlotte Hinault
Journal:  Orphanet J Rare Dis       Date:  2014-02-06       Impact factor: 4.123

7.  Probing the Inhibitor versus Chaperone Properties of sp²-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease.

Authors:  Teresa Mena-Barragán; M Isabel García-Moreno; Alen Sevšek; Tetsuya Okazaki; Eiji Nanba; Katsumi Higaki; Nathaniel I Martin; Roland J Pieters; José M García Fernández; Carmen Ortiz Mellet
Journal:  Molecules       Date:  2018-04-17       Impact factor: 4.411

8.  Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids.

Authors:  Elena M Sánchez-Fernández; M Isabel García-Moreno; Raquel García-Hernández; José M Padrón; José M García Fernández; Francisco Gamarro; Carmen Ortiz Mellet
Journal:  Molecules       Date:  2019-08-08       Impact factor: 4.411

9.  Synthesis of "All-Cis" Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors.

Authors:  Maria Giulia Davighi; Francesca Clemente; Camilla Matassini; Amelia Morrone; Andrea Goti; Macarena Martínez-Bailén; Francesca Cardona
Journal:  Molecules       Date:  2020-10-02       Impact factor: 4.411

Review 10.  Emerging novel concept of chaperone therapies for protein misfolding diseases.

Authors:  Yoshiyuki Suzuki
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2014       Impact factor: 3.493
  10 in total

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