75 years of mortality in the United States, 1935-2010.

While the overall risk of mortality decreased 60 percent over this 75-year period, there were fluctuations in the rate of decline most likely associated with changes in the broader environment. For example, the 29 percent decline in age-adjusted mortality in the earlier period from 1935 to 1954 was probably influenced by the introduction of various drugs such as antibiotics (2). In contrast, in the period 1955 to 1968, age-adjusted death rates decreased by only 2 percent, influenced in part by increases in diseases linked to tobacco use such as cancer and chronic lower respiratory diseases (3,4). In the most recent period from 1969 to 2010, significant progress in the prevention, diagnosis, and treatment of cardiovascular diseases (5) likely contributed to the 41 percent decline in age-adjusted mortality despite cancer continuing to increase from 1969 to 1990 and chronic lower respiratory diseases continuing to increase from 1969 to 1998. Because year-to-year changes in death rates are often small, one might not appreciate the full extent of progress in reducing mortality in the United States over the past ¾ of a century. For example, the 2010 age-adjusted death rate of 746.2 deaths per 100,000 population was just 0.5 percent lower than in 2009. However, the 2010 rate represented a 60 percent decrease from the 1935 age-adjusted death rate of 1,860.1 deaths per 100,000 population signaling significant progress in reducing the overall risk of death in the United States across all groups. All material appearing in this report is in the public domain and may be reproduced or copied without permission; citation as to source, however, is appreciated.