BACKGROUND: Previous studies indicate that increased QRS duration in ECG is related to the risk of all-cause death. However, the association of QRS duration with the risk of sudden cardiac death (SCD) is not well documented in large population-based studies. Our aim was to examine the relation of QRS duration with SCD in a population-based sample of men. METHODS AND RESULTS: This prospective study was based on a cohort of 2049 men aged 42 to 60 years at baseline with a 19-year follow-up, during which a total of 156 SCDs occurred. As a continuous variable, each 10-ms increase in QRS duration was associated with a 27% higher risk for SCD (relative risk, 1.27; 95% confidence interval, 1.14-1.40; P<0.001). Subjects with QRS duration of >110 ms (highest quintile) had a 2.50-fold risk for SCD (relative risk, 2.50; 95% confidence interval, 1.38-4.55; P=0.002) compared with those with QRS duration of <96 ms (lowest quintile), after adjustment for established key demographic and clinical risk factors (age, alcohol consumption, previous myocardial infarction, smoking, serum low- and high-density lipoprotein cholesterol, C-reactive protein, type 2 diabetes mellitus, body mass index, systolic blood pressure, and cardiorespiratory fitness). In addition to QRS duration, smoking, previous myocardial infarction, type 2 diabetes mellitus, cardiorespiratory fitness, body mass index, systolic blood pressure, and C-reactive protein were independently associated with the risk of SCD. CONCLUSIONS: QRS duration is an independent predictor of the risk of SCD and may have utility in estimating SCD risk in the general population.
BACKGROUND: Previous studies indicate that increased QRS duration in ECG is related to the risk of all-cause death. However, the association of QRS duration with the risk of sudden cardiac death (SCD) is not well documented in large population-based studies. Our aim was to examine the relation of QRS duration with SCD in a population-based sample of men. METHODS AND RESULTS: This prospective study was based on a cohort of 2049 men aged 42 to 60 years at baseline with a 19-year follow-up, during which a total of 156 SCDs occurred. As a continuous variable, each 10-ms increase in QRS duration was associated with a 27% higher risk for SCD (relative risk, 1.27; 95% confidence interval, 1.14-1.40; P<0.001). Subjects with QRS duration of >110 ms (highest quintile) had a 2.50-fold risk for SCD (relative risk, 2.50; 95% confidence interval, 1.38-4.55; P=0.002) compared with those with QRS duration of <96 ms (lowest quintile), after adjustment for established key demographic and clinical risk factors (age, alcohol consumption, previous myocardial infarction, smoking, serum low- and high-density lipoprotein cholesterol, C-reactive protein, type 2 diabetes mellitus, body mass index, systolic blood pressure, and cardiorespiratory fitness). In addition to QRS duration, smoking, previous myocardial infarction, type 2 diabetes mellitus, cardiorespiratory fitness, body mass index, systolic blood pressure, and C-reactive protein were independently associated with the risk of SCD. CONCLUSIONS: QRS duration is an independent predictor of the risk of SCD and may have utility in estimating SCD risk in the general population.
Authors: Pentti M Rautaharju; Zhu-ming Zhang; Richard E Gregg; Wesley K Haisty; Mara Z Vitolins; Anne B Curtis; James Warren; Milan B Horaĉek; Sophia H Zhou; Elsayed Z Soliman Journal: J Electrocardiol Date: 2013-07-01 Impact factor: 1.438
Authors: Matthew G Whitbeck; Richard J Charnigo; Jignesh Shah; Gustavo Morales; Steve W Leung; Brandon Fornwalt; Alison L Bailey; Khaled Ziada; Vincent L Sorrell; Milagros M Zegarra; Jenks Thompson; Neil Aboul Hosn; Charles L Campbell; John Gurley; Paul Anaya; David C Booth; Luigi Di Biase; Andrea Natale; Susan Smyth; David J Moliterno; Claude S Elayi Journal: Europace Date: 2013-12-23 Impact factor: 5.214