| Literature DB >> 22615199 |
Yudai Suzuki1, Motomu Kanai, Shigeki Matsunaga.
Abstract
Access to chiral isoindolinones: The Mg-catalyzed enantioselective benzylic C-H bond functionalization of isoindolinones is described. A Bu(2) Mg/Schiff base catalyst (1:1) promoted the enantioselective addition of N-Boc-isoindolinones to aryl, heteroaryl, alkenyl, and alkyl imines, giving 3-substituted isoindolinones in 84-99 % ee and 50:50-91:9 d.r. (see scheme).Entities:
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Year: 2012 PMID： 22615199 DOI： 10.1002/chem.201200821
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236