Literature DB >> 22613191

Combined chemotherapy and ALA-based photodynamic therapy in leukemic murine cells.

Berenice Diez1, Glenda Ernst, María Julieta Teijo, Alcira Batlle, Silvia Hajos, Haydée Fukuda.   

Abstract

The effects of combined administration of doxorubicin (DOX) and vincristine (VCR), with 5-aminolevulinic acid photodynamic treatment (ALA-PDT), were analyzed in sensitive murine leukemic cell lines (LBR-) and DOX and VCR chemoresistant LBR-D160 and LBR-V160 cell lines. Low doses of DOX and VCR increased anti-cancer effect of ALA-PDT in LBR-cells. Decrease in cell survival was higher when the combination VCR+ALA-PDT was used compared to DOX+ALA-PDT. Resistant cell lines LBR-D160 and LBR-V160 were sensitive to ALA-PDT; however, no changes occured when combining therapies. Thus, ALA-PDT can overcome drug resistance and is a good candidate for using treating multidrug resistant (MDR) cells.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22613191     DOI： 10.1016/j.leukres.2012.04.027

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  9 in total

1.  Inhibition of the HIF-1 Survival Pathway as a Strategy to Augment Photodynamic Therapy Efficacy.

Authors:  Mark J de Keijzer; Daniel J de Klerk; Lianne R de Haan; Robert T van Kooten; Leonardo P Franchi; Lionel M Dias; Tony G Kleijn; Diederick J van Doorn; Michal Heger
Journal:  Methods Mol Biol       Date:  2022

2.  Towards novel anti-tumor strategies for hepatic cancer: ɛ-viniferin in combination with vincristine displays pharmacodynamic synergy at lower doses in HepG2 cells.

Authors:  Filiz Özdemir; Gülşen Akalın; Mesut Şen; Nur Ipek Önder; Arzu Işcan; H Mehtap Kutlu; Zerrin Incesu
Journal:  OMICS       Date:  2013-12-17

3.  Combination of Near Infrared Light-Activated Photodynamic Therapy Mediated by Indocyanine Green with Etoposide to Treat Non-Small-Cell Lung Cancer.

Authors:  Ting Luo; Qinrong Zhang; Qing-Bin Lu
Journal:  Cancers (Basel)       Date:  2017-06-05       Impact factor: 6.639

4.  Photodynamic Synergistic Effect of Pheophorbide a and Doxorubicin in Combined Treatment against Tumoral Cells.

Authors:  Rubén Ruiz-González; Paula Milán; Roger Bresolí-Obach; Juan Carlos Stockert; Angeles Villanueva; Magdalena Cañete; Santi Nonell
Journal:  Cancers (Basel)       Date:  2017-02-17       Impact factor: 6.639

5.  Enhanced photo/chemo combination efficiency against bladder tumor by encapsulation of DOX and ZnPC into in situ-formed thermosensitive polymer hydrogel.

Authors:  Zhongming Huang; He Xiao; Xiangyun Lu; Weigang Yan; Zhigang Ji
Journal:  Int J Nanomedicine       Date:  2018-11-19

6.  Systemic MEK inhibition enhances the efficacy of 5-aminolevulinic acid-photodynamic therapy.

Authors:  Vipin Shankar Chelakkot; Jayoti Som; Ema Yoshioka; Chantel P Rice; Suzette G Rutihinda; Kensuke Hirasawa
Journal:  Br J Cancer       Date:  2019-09-25       Impact factor: 7.640

7.  Cell membranes targeted unimolecular prodrug for programmatic photodynamic-chemo therapy.

Authors:  Jie Yuan; Rong Peng; Dongdong Su; Xingxing Zhang; Hepeng Zhao; Xiujuan Zhuang; Mei Chen; Xiaobing Zhang; Lin Yuan
Journal:  Theranostics       Date:  2021-01-19       Impact factor: 11.556

8.  Targeting tumour energy metabolism potentiates the cytotoxicity of 5-aminolevulinic acid photodynamic therapy.

Authors:  J P Golding; T Wardhaugh; L Patrick; M Turner; J B Phillips; J I Bruce; S G Kimani
Journal:  Br J Cancer       Date:  2013-07-16       Impact factor: 7.640

9.  Temperature-controlled, phase-transition ultrasound imaging-guided photothermal-chemotherapy triggered by NIR light.

Authors:  Wei Li; Wanqing Hou; Xiaomeng Guo; Lihua Luo; Qingpo Li; Chunqi Zhu; Jie Yang; Jiang Zhu; Yongzhong Du; Jian You
Journal:  Theranostics       Date:  2018-04-30       Impact factor: 11.556
  9 in total

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