| Literature DB >> 22612227 |
Simone Kosol1, Evelyne Schrank, Mirjana Bukvić Krajačić, Gabriel E Wagner, N Helge Meyer, Christoph Göbl, Gerald N Rechberger, Klaus Zangger, Predrag Novak.
Abstract
Interactions of macrolide antibiotics with biological membranes contribute to their bioavailability but are also involved in the formation of phospholipidosis, which is caused by the inhibition of phospholipase A(1) activity. We determined the interaction strength and localization of macrolide antibiotics with membrane-mimetics. Macrolides bind to membrane-mimetics with the positively charged amino groups being close to the micelle surface and thereby protect the lipids from being degraded by phospholipase A(1) rather than inhibiting the enzyme.Entities:
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Year: 2012 PMID： 22612227 DOI： 10.1021/jm300647f
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446