O Sany1, K Singh, S Jha. 1. Pan-Birmingham Gynaecology Cancer Centre, Sandwell and West Birmingham NHS Trust, UK. omarsany@hotmail.com
Abstract
OBJECTIVE: We conducted a study to evaluate the correlation between pre-operative endometrial sampling to the final endometrial cancer histology, in particular the non-endometrioid subtypes. METHODS: This involved 191 hysterectomy specimens of patients undergoing treatment at the Pan-Birmingham Gynaecological Regional Cancer Centre (BGCC) over a two-year period (2006-2007). RESULTS: The majority of the patients in this study were found to have endometrioid histology subtype (140/191, 73%). However, the non-endometrioid histologic subtypes were well presented in our population (51/191, 27%). We found good correlation for endometriod histology subtype (78%) and certain types of the non-endometrioid cell types (carcinosarcoma 90%, uterine papillary serous carcinoma 67%, clear cell carcinoma 67%) but poor in sarcomas (40%). Our results also demonstrated that both pre-operative endometrial sampling methods (curettage and pipelle biopsy) were reliable in identifying endometrioid and non-endometrioid cancer cell types, with sensitivities of 96.5% and 86.5%, respectively. CONCLUSION: We concluded that preoperative endometrial sampling had good overall histological correlation to hysterectomised corpus specimen. This is especially so for the endometrioid and certain subtypes of the non-endometrioid endometrial cancer cells.
OBJECTIVE: We conducted a study to evaluate the correlation between pre-operative endometrial sampling to the final endometrial cancer histology, in particular the non-endometrioid subtypes. METHODS: This involved 191 hysterectomy specimens of patients undergoing treatment at the Pan-Birmingham Gynaecological Regional Cancer Centre (BGCC) over a two-year period (2006-2007). RESULTS: The majority of the patients in this study were found to have endometrioid histology subtype (140/191, 73%). However, the non-endometrioid histologic subtypes were well presented in our population (51/191, 27%). We found good correlation for endometriod histology subtype (78%) and certain types of the non-endometrioid cell types (carcinosarcoma 90%, uterine papillary serous carcinoma 67%, clear cell carcinoma 67%) but poor in sarcomas (40%). Our results also demonstrated that both pre-operative endometrial sampling methods (curettage and pipelle biopsy) were reliable in identifying endometrioid and non-endometrioid cancer cell types, with sensitivities of 96.5% and 86.5%, respectively. CONCLUSION: We concluded that preoperative endometrial sampling had good overall histological correlation to hysterectomised corpus specimen. This is especially so for the endometrioid and certain subtypes of the non-endometrioid endometrial cancer cells.
Authors: Aline Talhouk; Lien N Hoang; Melissa K McConechy; Quentin Nakonechny; Joyce Leo; Angela Cheng; Samuel Leung; Winnie Yang; Amy Lum; Martin Köbel; Cheng-Han Lee; Robert A Soslow; David G Huntsman; C Blake Gilks; Jessica N McAlpine Journal: Gynecol Oncol Date: 2016-07-14 Impact factor: 5.482
Authors: Noemie Body; Vincent Lavoué; Olivier De Kerdaniel; Fabrice Foucher; Sébastien Henno; Aurélie Cauchois; Bruno Laviolle; Marc Leblanc; Jean Levêque Journal: BMC Cancer Date: 2016-07-19 Impact factor: 4.430
Authors: Zuzana Danková; Dušan Braný; Dana Dvorská; Marcela Ňachajová; Roman Fiolka; Marián Grendár; Jozef Hatok; Peter Kubatka; Veronika Holubeková; Erika Halašová; Tibor Bielik; Pavol Žúbor Journal: Int J Mol Med Date: 2018-09-12 Impact factor: 4.101