Literature DB >> 22611424

Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ).

Jeffrey M Peters1, Jose L Morales, Frank J Gonzalez.   

Abstract

Critical physiological roles of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) include the regulation glucose and lipid homeostasis, cellular differentiation, and modulation of inflammation. The potential for targeting PPARβ/δ for the prevention and treatment of metabolic diseases or cancer, is compromised because of major inconsistencies in the literature. This is due primarily to uncertainty regarding the effect of PPARβ/δ and its activation on cell proliferation, apoptosis and cell survival. This review summarizes both the confirmed and conflicting mechanisms that have been described for PPARβ/δ and the potential for targeting this nuclear receptor for the prevention and treatment of colon cancer.

Entities:  

Year:  2011        PMID： 22611424      PMCID： PMC3352671          DOI： 10.1016/j.ddmec.2011.11.002

Source DB:  PubMed          Journal:  Drug Discov Today Dis Mech        ISSN： 1740-6765


  70 in total

1.  Critical roles of PPAR beta/delta in keratinocyte response to inflammation.

Authors:  N S Tan; L Michalik; N Noy; R Yasmin; C Pacot; M Heim; B Flühmann; B Desvergne; W Wahli
Journal:  Genes Dev       Date:  2001-12-15       Impact factor: 11.361

2.  PPARδ deficient mice develop elevated Th1/Th17 responses and prolonged experimental autoimmune encephalomyelitis.

Authors:  Saravanan Kanakasabai; Crystal C Walline; Sharmistha Chakraborty; John J Bright
Journal:  Brain Res       Date:  2010-12-28       Impact factor: 3.252

3.  PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.

Authors:  David Alvarez-Guardia; Xavier Palomer; Teresa Coll; Lucía Serrano; Ricardo Rodríguez-Calvo; Mercy M Davidson; Manuel Merlos; Ilhem El Kochairi; Liliane Michalik; Walter Wahli; Manuel Vázquez-Carrera
Journal:  Biochim Biophys Acta       Date:  2010-11-09

Review 4.  PPAR-beta/delta agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home.

Authors:  Andrew N Billin
Journal:  Expert Opin Investig Drugs       Date:  2008-10       Impact factor: 6.206

5.  Peroxisome proliferator-activated receptor delta agonists attenuated the C-reactive protein-induced pro-inflammation in cardiomyocytes and H9c2 cardiomyoblasts.

Authors:  Yao-Jen Liang; Chao-Yi Chen; Shiow-Jen Juang; Ling-Ping Lai; Kou-Gi Shyu; Bao-Wei Wang; Shannen Yuan-Chun Liu; Jyh-Gang Leu
Journal:  Eur J Pharmacol       Date:  2010-06-28       Impact factor: 4.432

6.  Biological function and prognostic significance of peroxisome proliferator-activated receptor δ in rectal cancer.

Authors:  Lie Yang; Hong Zhang; Zong-Guang Zhou; Hui Yan; G Adell; Xiao-Feng Sun
Journal:  Clin Cancer Res       Date:  2011-04-29       Impact factor: 12.531

7.  Nonsteroidal anti-inflammatory drugs induced endothelial apoptosis by perturbing peroxisome proliferator-activated receptor-delta transcriptional pathway.

Authors:  Jun-Yang Liou; Chia-Ching Wu; Bo-Rui Chen; Linju B Yen; Kenneth K Wu
Journal:  Mol Pharmacol       Date:  2008-08-04       Impact factor: 4.436

8.  Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis.

Authors:  Xiangsheng Zuo; Zhanglong Peng; Micheline J Moussalli; Jeffrey S Morris; Russell R Broaddus; Susan M Fischer; Imad Shureiqi
Journal:  J Natl Cancer Inst       Date:  2009-05-12       Impact factor: 13.506

9.  Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis.

Authors:  Basilia Zingarelli; Giovanna Piraino; Paul W Hake; Michael O'Connor; Alvin Denenberg; Hongkuan Fan; James A Cook
Journal:  Am J Pathol       Date:  2010-08-13       Impact factor: 5.770

10.  Reverse crosstalk of TGFβ and PPARβ/δ signaling identified by transcriptional profiling.

Authors:  Josefine Stockert; Till Adhikary; Kerstin Kaddatz; Florian Finkernagel; Wolfgang Meissner; Sabine Müller-Brüsselbach; Rolf Müller
Journal:  Nucleic Acids Res       Date:  2010-09-15       Impact factor: 16.971
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  12 in total

Review 1.  The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention.

Authors:  Jeffrey M Peters; Yatrik M Shah; Frank J Gonzalez
Journal:  Nat Rev Cancer       Date:  2012-02-09       Impact factor: 60.716

2.  Peroxisome proliferator-activated receptor β/δ cross talks with E2F and attenuates mitosis in HRAS-expressing cells.

Authors:  Bokai Zhu; Combiz Khozoie; Moses T Bility; Christina H Ferry; Nicholas Blazanin; Adam B Glick; Frank J Gonzalez; Jeffrey M Peters
Journal:  Mol Cell Biol       Date:  2012-04-02       Impact factor: 4.272

Review 3.  Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer.

Authors:  Jeffrey M Peters; Dae J Kim; Moses T Bility; Michael G Borland; Bokai Zhu; Frank J Gonzalez
Journal:  Mol Carcinog       Date:  2019-05-06       Impact factor: 4.784

4.  Activation of peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) inhibits human breast cancer cell line tumorigenicity.

Authors:  Pei-Li Yao; Jose L Morales; Bokai Zhu; Boo-Hyon Kang; Frank J Gonzalez; Jeffrey M Peters
Journal:  Mol Cancer Ther       Date:  2014-01-24       Impact factor: 6.261

Review 5.  Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for Cancer Chemoprevention.

Authors:  Jeffrey M Peters; Pei-Li Yao; Frank J Gonzalez
Journal:  Curr Pharmacol Rep       Date:  2015

Review 6.  Peroxisome proliferator-activated receptors (PPARs) are potential drug targets for cancer therapy.

Authors:  Qian Gou; Xin Gong; Jianhua Jin; Juanjuan Shi; Yongzhong Hou
Journal:  Oncotarget       Date:  2017-07-27

7.  Analysis of the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) cistrome reveals novel co-regulatory role of ATF4.

Authors:  Combiz Khozoie; Michael G Borland; Bokai Zhu; Songjoon Baek; Sam John; Gordon L Hager; Yatrik M Shah; Frank J Gonzalez; Jeffrey M Peters
Journal:  BMC Genomics       Date:  2012-11-24       Impact factor: 3.969

8.  Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice.

Authors:  Gayathri Balandaram; Lance R Kramer; Boo-Hyon Kang; Iain A Murray; Gary H Perdew; Frank J Gonzalez; Jeffrey M Peters
Journal:  Toxicology       Date:  2016-07-15       Impact factor: 4.571

9.  PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling.

Authors:  B Zhu; C H Ferry; N Blazanin; M T Bility; C Khozoie; B-H Kang; A B Glick; F J Gonzalez; J M Peters
Journal:  Oncogene       Date:  2013-11-11       Impact factor: 9.867

10.  Alleviation of Toxicity Caused by Overactivation of Pparα through Pparα-Inducible miR-181a2.

Authors:  Yanjie Cheng; Zhuying Wei; Shengsong Xie; You Peng; Yi Yan; Dan Qin; Shenghui Liu; Yanling Xu; Guangpeng Li; Lisheng Zhang
Journal:  Mol Ther Nucleic Acids       Date:  2017-09-28
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