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Literature DB >> 22610725

Tailored poly(2-oxazoline) polymer brushes to control protein adsorption and cell adhesion.

Ning Zhang¹, Tilo Pompe, Ihsan Amin, Robert Luxenhofer, Carsten Werner, Rainer Jordan.

Abstract

POx bottle-brush brushes (BBBs) are synthesized by SIPGP of 2-isopropenyl-2-oxazoline and consecutive LCROP of 2-oxazolines on 3-aminopropyltrimethoxysilane-modified silicon substrates. The side chain hydrophilicity and polarity are varied. The impact of the chemical composition and architecture of the BBB upon protein (fibronectin) adsorption and endothelial cell adhesion are investigated and prove extremely low protein adsorption and cell adhesion on BBBs with hydrophilic side chains such as poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline). The influence of the POx side chain terminal function upon adsorption and adhesion is minor but the side chain length has a significant effect on bioadsorption.

Entities: Chemical Disease Gene

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Year: 2012 PMID： 22610725 DOI： 10.1002/mabi.201200026

Source DB: PubMed Journal: Macromol Biosci ISSN： 1616-5187 Impact factor: 4.979

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Cited

19 in total

1. Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: preparation, in vitro and in vivo evaluation.

Authors: Zhijian He; Anita Schulz; Xiaomeng Wan; Joshua Seitz; Herdis Bludau; Daria Y Alakhova; David B Darr; Charles M Perou; Rainer Jordan; Iwao Ojima; Alexander V Kabanov; Robert Luxenhofer
Journal: J Control Release Date: 2015-02-26 Impact factor: 9.776

2. POxylation as an alternative stealth coating for biomedical applications.

Authors: Herdis Bludau; Anna E Czapar; Andrzej S Pitek; Sourabh Shukla; Rainer Jordan; Nicole F Steinmetz
Journal: Eur Polym J Date: 2016-11-05 Impact factor: 4.598

3. Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy.

Authors: Settimio Pacelli; Vijayan Manoharan; Anna Desalvo; Nikita Lomis; Kartikeya Singh Jodha; Satya Prakash; Arghya Paul
Journal: J Mater Chem B Date: 2015-10-16 Impact factor: 6.331

4. A Low Protein Binding Cationic Poly(2-oxazoline) as Non-Viral Vector.

Authors: Zhijian He; Lei Miao; Rainer Jordan; Devika S-Manickam; Robert Luxenhofer; Alexander V Kabanov
Journal: Macromol Biosci Date: 2015-04-02 Impact factor: 4.979

5. Maleimide-Functionalized Poly(2-Oxazoline)s and Their Conjugation to Elastin-Like Polypeptides.

Authors: Jonas F Nawroth; Jonathan R McDaniel; Ashutosh Chilkoti; Rainer Jordan; Robert Luxenhofer
Journal: Macromol Biosci Date: 2016-01-12 Impact factor: 4.979

6. Poly(2-substituted-2-oxazoline) surfaces for dermal fibroblasts adhesion and detachment.

Authors: Andrzej Dworak; Alicja Utrata-Wesołek; Natalia Oleszko; Wojciech Wałach; Barbara Trzebicka; Jacek Anioł; Aleksander L Sieroń; Agnieszka Klama-Baryła; Marek Kawecki
Journal: J Mater Sci Mater Med Date: 2014-01-04 Impact factor: 3.896

7. C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes.

Authors: Regina Tavano; Luca Gabrielli; Elisa Lubian; Chiara Fedeli; Silvia Visentin; Patrizia Polverino De Laureto; Giorgio Arrigoni; Alessandra Geffner-Smith; Fangfang Chen; Dmitri Simberg; Giulia Morgese; Edmondo M Benetti; Linping Wu; Seyed Moein Moghimi; Fabrizio Mancin; Emanuele Papini
Journal: ACS Nano Date: 2018-05-23 Impact factor: 15.881