BACKGROUND: The association between body mass index (BMI) and lung cancer is still disputed because of possible residual confounding by smoking and preclinical weight loss in case-control studies. We examined this association using data from the multicenter ICARE study in France, a large, population-based case-control study. METHODS: A total of 2,625 incident lung cancer cases and 3,381 controls were included. Weight was collected at interview, 2 years before the interview, and at age 30. Lifetime smoking exposure was calculated using the comprehensive smoking index (CSI). Adjusted odds ratios (aORs) and 95 % confidence intervals were estimated by unconditional logistic regression and controlled for age, area, education, CSI, occupational exposure, previous chronic bronchitis, and parental history of lung cancer. We also examined the role of weight change. Analyses were stratified by smoking status and sex. RESULTS: When compared with that of men with normal BMI 2 years before the interview, lung cancer aORs (95 % CI) among men with BMIs of <18.5, 25-29.9, 30-32.4, and ≥32.5 kg/m(2) were 2.7 (95 % CI 1.2-6.2), 0.9 (95 % CI 0.7-1.1), 0.8 (95 % CI 0.6-1.1), and 0.8 (95 % CI 0.6-1.0), respectively (p(trend) = 0.02). Results were more pronounced among current smokers and were similar in men and women. Weight gain over time was associated with a significant decreased risk of lung cancer. CONCLUSIONS: We found an inverse dose-dependent association between lung cancer risk and BMI 2 years prior to interview in current smokers. IMPACT STATEMENT: BMI might be an individual factor impacting the risk of lung cancer related to smoking's carcinogen-induced DNA damage.
BACKGROUND: The association between body mass index (BMI) and lung cancer is still disputed because of possible residual confounding by smoking and preclinical weight loss in case-control studies. We examined this association using data from the multicenter ICARE study in France, a large, population-based case-control study. METHODS: A total of 2,625 incident lung cancer cases and 3,381 controls were included. Weight was collected at interview, 2 years before the interview, and at age 30. Lifetime smoking exposure was calculated using the comprehensive smoking index (CSI). Adjusted odds ratios (aORs) and 95 % confidence intervals were estimated by unconditional logistic regression and controlled for age, area, education, CSI, occupational exposure, previous chronic bronchitis, and parental history of lung cancer. We also examined the role of weight change. Analyses were stratified by smoking status and sex. RESULTS: When compared with that of men with normal BMI 2 years before the interview, lung cancer aORs (95 % CI) among men with BMIs of <18.5, 25-29.9, 30-32.4, and ≥32.5 kg/m(2) were 2.7 (95 % CI 1.2-6.2), 0.9 (95 % CI 0.7-1.1), 0.8 (95 % CI 0.6-1.1), and 0.8 (95 % CI 0.6-1.0), respectively (p(trend) = 0.02). Results were more pronounced among current smokers and were similar in men and women. Weight gain over time was associated with a significant decreased risk of lung cancer. CONCLUSIONS: We found an inverse dose-dependent association between lung cancer risk and BMI 2 years prior to interview in current smokers. IMPACT STATEMENT: BMI might be an individual factor impacting the risk of lung cancer related to smoking's carcinogen-induced DNA damage.
Authors: Gwenn Menvielle; Thérèse Truong; Fatima Jellouli; Isabelle Stücker; Hermann Brenner; John K Field; H Dean Hosgood; Qing Lan; Maria Teresa Landi; Rayjean J Hung; Philip Lazarus; John McLaughlin; Hal Morgenstern; Joshua E Muscat; Alberto Ruano-Ravina; Ann G Schwartz; Adeline Seow; Margaret R Spitz; Adonina Tardon; Zuo-Feng Zhang; Danièle Luce Journal: Epidemiology Date: 2014-11 Impact factor: 4.822
Authors: Chi Gao; Chirag J Patel; Kyriaki Michailidou; Ulrike Peters; Jian Gong; Joellen Schildkraut; Fredrick R Schumacher; Wei Zheng; Paolo Boffetta; Isabelle Stucker; Walter Willett; Stephen Gruber; Douglas F Easton; David J Hunter; Thomas A Sellers; Christopher Haiman; Brian E Henderson; Rayjean J Hung; Christopher Amos; Brandon L Pierce; Sara Lindström; Peter Kraft Journal: Int J Epidemiol Date: 2016-07-17 Impact factor: 7.196
Authors: Nikmah Utami Dewi; Hendriek C Boshuizen; Mattias Johansson; Paolo Vineis; Ellen Kampman; Annika Steffen; Anne Tjønneland; Jytte Halkjær; Kim Overvad; Gianluca Severi; Guy Fagherazzi; Marie-Christine Boutron-Ruault; Rudolf Kaaks; Kuanrong Li; Heiner Boeing; Antonia Trichopoulou; Christina Bamia; Eleni Klinaki; Rosario Tumino; Domenico Palli; Amalia Mattiello; Giovanna Tagliabue; Petra H Peeters; Roel Vermeulen; Elisabete Weiderpass; Inger Torhild Gram; José María Huerta; Antonio Agudo; María-José Sánchez; Eva Ardanaz; Miren Dorronsoro; José Ramón Quirós; Emily Sonestedt; Mikael Johansson; Kjell Grankvist; Tim Key; Kay-Tee Khaw; Nick Wareham; Amanda J Cross; Teresa Norat; Elio Riboli; Anouar Fanidi; David Muller; H Bas Bueno-de-Mesquita Journal: Am J Epidemiol Date: 2016-07-01 Impact factor: 4.897