Literature DB >> 22610567

Isolation and characterization of human prostate stem/progenitor cells.

Changyong Guo1, Baohui Zhang, Isla P Garraway.   

Abstract

Isolation of prostate epithelial cells with stem/progenitor characteristics may enable further evaluation of the hierarchy of prostate glandular development and malignant transformation. Prostate epithelial cells capable of sphere formation in semisolid cultures possess stem/progenitor cell characteristics. This is demonstrated by self-renewal (via indefinite passaging) and in vivo differentiation into prostate tubules with discreet basal and luminal layers. Here, we describe a method for isolating prostate stem/progenitor cells from human tissues via in vitro prostasphere formation. Prostate tissue regeneration using human prostaspheres is also described, enabling the differentiation potential of sphere-forming cells to be observed.

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Year:  2012        PMID： 22610567     DOI： 10.1007/978-1-61779-815-3_18

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  8 in total

1.  Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.

Authors:  Jean-Philippe P Theurillat; Namrata D Udeshi; Wesley J Errington; Tanya Svinkina; Sylvan C Baca; Marius Pop; Peter J Wild; Mirjam Blattner; Anna C Groner; Mark A Rubin; Holger Moch; Gilbert G Prive; Steven A Carr; Levi A Garraway
Journal:  Science       Date:  2014-10-02       Impact factor: 47.728

2.  Differential Actions of Estrogen Receptor α and β via Nongenomic Signaling in Human Prostate Stem and Progenitor Cells.

Authors:  Shyama Majumdar; Jaqueline C Rinaldi; Neha R Malhotra; Lishi Xie; Dan-Ping Hu; Timothy D Gauntner; Harinder S Grewal; Wen-Yang Hu; Sung Hoon Kim; John A Katzenellenbogen; Susan Kasper; Gail S Prins
Journal:  Endocrinology       Date:  2019-11-01       Impact factor: 4.736

3.  Stromal modulation of bladder cancer-initiating cells in a subcutaneous tumor model.

Authors:  Elizabeth M Peek; David R Li; Hanwei Zhang; Hyun Pyo Kim; Baohui Zhang; Isla P Garraway; Arnold I Chin
Journal:  Am J Cancer Res       Date:  2012-11-20       Impact factor: 6.166

4.  Quantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysis.

Authors:  Ville Härmä; Hannu-Pekka Schukov; Antti Happonen; Ilmari Ahonen; Johannes Virtanen; Harri Siitari; Malin Åkerfelt; Jyrki Lötjönen; Matthias Nees
Journal:  PLoS One       Date:  2014-05-08       Impact factor: 3.240

5.  Induced pluripotency of human prostatic epithelial cells.

Authors:  Hongjuan Zhao; Ning Sun; Sarah R Young; Rosalie Nolley; Jennifer Santos; Joseph C Wu; Donna M Peehl
Journal:  PLoS One       Date:  2013-05-22       Impact factor: 3.240

6.  Single luminal epithelial progenitors can generate prostate organoids in culture.

Authors:  Chee Wai Chua; Maho Shibata; Ming Lei; Roxanne Toivanen; LaMont J Barlow; Sarah K Bergren; Ketan K Badani; James M McKiernan; Mitchell C Benson; Hanina Hibshoosh; Michael M Shen
Journal:  Nat Cell Biol       Date:  2014-09-21       Impact factor: 28.824

7.  Beyond the androgen receptor: new approaches to treating metastatic prostate cancer. Report of the 2013 Prouts Neck Prostate Cancer Meeting.

Authors:  Kenneth J Pienta; Guneet Walia; Jonathan W Simons; Howard R Soule
Journal:  Prostate       Date:  2014-02       Impact factor: 4.104

8.  Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration.

Authors:  Baotong Zhang; Xinpei Ci; Ran Tao; Jianping Jenny Ni; Xiaoyan Xuan; Jamie L King; Siyuan Xia; Yixiang Li; Henry F Frierson; Dong-Kee Lee; Jianming Xu; Adeboye O Osunkoya; Jin-Tang Dong
Journal:  Nat Commun       Date:  2020-02-21       Impact factor: 14.919
  8 in total

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