Literature DB >> 22610427

A gain-of-function mutation in gating of Corynebacterium glutamicum NCgl1221 causes constitutive glutamate secretion.

Yoshitaka Nakayama1, Kenjiro Yoshimura, Hidetoshi Iida.   

Abstract

The A-to-V mutation at position 111 (A111V) in the mechanosensitive channel NCgl1221 (MscCG) causes constitutive glutamate secretion in Corynebacterium glutamicum. Patch clamp experiments revealed that NCgl1221 (A111V) had a significantly smaller gating threshold than the wild-type counterpart and displayed strong hysteresis, suggesting that the gain-of-function mutation in the gating of NCgl1221 leads to the oversecretion of glutamate.

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Year:  2012        PMID： 22610427      PMCID： PMC3416442          DOI： 10.1128/AEM.01310-12

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  14 in total

1.  Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel.

Authors:  Randal B Bass; Pavel Strop; Margaret Barclay; Douglas C Rees
Journal:  Science       Date:  2002-11-22       Impact factor: 47.728

2.  Pressure-sensitive ion channel in Escherichia coli.

Authors:  B Martinac; M Buechner; A H Delcour; J Adler; C Kung
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

3.  Ionic regulation of MscK, a mechanosensitive channel from Escherichia coli.

Authors:  Yuezhou Li; Paul C Moe; Subramanian Chandrasekaran; Ian R Booth; Paul Blount
Journal:  EMBO J       Date:  2002-10-15       Impact factor: 11.598

4.  Functional design of bacterial mechanosensitive channels. Comparisons and contrasts illuminated by random mutagenesis.

Authors:  Kuniyuki Okada; Paul C Moe; Paul Blount
Journal:  J Biol Chem       Date:  2002-05-15       Impact factor: 5.157

5.  Investigation of phosphorylation status of OdhI protein during penicillin- and Tween 40-triggered glutamate overproduction by Corynebacterium glutamicum.

Authors:  Jongpill Kim; Takashi Hirasawa; Masaki Saito; Chikara Furusawa; Hiroshi Shimizu
Journal:  Appl Microbiol Biotechnol       Date:  2011-04-19       Impact factor: 4.813

6.  Expression and localization of the Corynebacterium glutamicum NCgl1221 protein encoding an L-glutamic acid exporter.

Authors:  Wenjuan Yao; Xiaozhao Deng; Miao Liu; Pu Zheng; Zhihao Sun; Yun Zhang
Journal:  Microbiol Res       Date:  2009-02-23       Impact factor: 5.415

7.  Effect of biotin on the bacterial formation of glutamic acid. I. Glutamate formation and cellular premeability of amino acids.

Authors:  I SHIIO; S I OTSUKA; M TAKAHASHI
Journal:  J Biochem       Date:  1962-01       Impact factor: 3.387

8.  Mutations of the Corynebacterium glutamicum NCgl1221 gene, encoding a mechanosensitive channel homolog, induce L-glutamic acid production.

Authors:  Jun Nakamura; Seiko Hirano; Hisao Ito; Masaaki Wachi
Journal:  Appl Environ Microbiol       Date:  2007-05-18       Impact factor: 4.792

9.  Purification of the small mechanosensitive channel of Escherichia coli (MscS): the subunit structure, conduction, and gating characteristics in liposomes.

Authors:  Sergei Sukharev
Journal:  Biophys J       Date:  2002-07       Impact factor: 4.033

10.  The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution.

Authors:  Wenjian Wang; Susan S Black; Michelle D Edwards; Samantha Miller; Emma L Morrison; Wendy Bartlett; Changjiang Dong; James H Naismith; Ian R Booth
Journal:  Science       Date:  2008-08-29       Impact factor: 47.728
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  8 in total

1.  MscCG from Corynebacterium glutamicum: functional significance of the C-terminal domain.

Authors:  Michael Becker; Reinhard Krämer
Journal:  Eur Biophys J       Date:  2015-06-02       Impact factor: 1.733

2.  Electrophysiological characterization of the mechanosensitive channel MscCG in Corynebacterium glutamicum.

Authors:  Yoshitaka Nakayama; Kenjiro Yoshimura; Hidetoshi Iida
Journal:  Biophys J       Date:  2013-09-17       Impact factor: 4.033

3.  A Novel Corynebacterium glutamicum l-Glutamate Exporter.

Authors:  Yu Wang; Guoqiang Cao; Deyu Xu; Liwen Fan; Xinyang Wu; Xiaomeng Ni; Shuxin Zhao; Ping Zheng; Jibin Sun; Yanhe Ma
Journal:  Appl Environ Microbiol       Date:  2018-03-01       Impact factor: 4.792

Review 4.  MscS-like mechanosensitive channels in plants and microbes.

Authors:  Margaret E Wilson; Grigory Maksaev; Elizabeth S Haswell
Journal:  Biochemistry       Date:  2013-08-15       Impact factor: 3.162

Review 5.  Corynebacterium glutamicum mechanosensitive channels: towards unpuzzling "glutamate efflux" for amino acid production.

Authors:  Yoshitaka Nakayama; Ken-Ichi Hashimoto; Yasuyuki Sawada; Masahiro Sokabe; Hisashi Kawasaki; Boris Martinac
Journal:  Biophys Rev       Date:  2018-09-12

6.  Evolutionary specialization of MscCG, an MscS-like mechanosensitive channel, in amino acid transport in Corynebacterium glutamicum.

Authors:  Yoshitaka Nakayama; Kosuke Komazawa; Navid Bavi; Ken-Ichi Hashimoto; Hisashi Kawasaki; Boris Martinac
Journal:  Sci Rep       Date:  2018-08-27       Impact factor: 4.379

Review 7.  zzm321990 Corynebacterium glutamicum Mechanosensing: From Osmoregulation to L-Glutamate Secretion for the Avian Microbiota-Gut-Brain Axis.

Authors:  Yoshitaka Nakayama
Journal:  Microorganisms       Date:  2021-01-19

8.  Essentiality of c-di-AMP in Bacillus subtilis: Bypassing mutations converge in potassium and glutamate homeostasis.

Authors:  Larissa Krüger; Christina Herzberg; Hermann Rath; Tiago Pedreira; Till Ischebeck; Anja Poehlein; Jan Gundlach; Rolf Daniel; Uwe Völker; Ulrike Mäder; Jörg Stülke
Journal:  PLoS Genet       Date:  2021-01-22       Impact factor: 5.917
  8 in total

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