Literature DB >> 22609907

Needs for an expanded ontology-based classification of adverse drug reactions and related mechanisms.

P E Zhichkin1, B D Athey, M I Avigan, D R Abernethy.   

Abstract

The growing significance of bioinformatics and systems biology in drug safety research requires a system of adverse-event classification that goes beyond a simple vocabulary. This opinion piece outlines the need for development of an ontology-based framework of describing adverse drug reactions (ADRs) and describes the potential applications for such a framework.

Mesh：

Year:  2012        PMID： 22609907     DOI： 10.1038/clpt.2012.41

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  9 in total

1.  Towards precision informatics of pharmacovigilance: OAE-CTCAE mapping and OAE-based representation and analysis of adverse events in patients treated with cancer drugs.

Authors:  Mei U Wong; Rebecca Racz; Edison Ong; Yongqun He
Journal:  AMIA Annu Symp Proc       Date:  2018-04-16

2.  The potential of translational bioinformatics approaches for pharmacology research.

Authors:  Lang Li
Journal:  Br J Clin Pharmacol       Date:  2015-06-01       Impact factor: 4.335

3.  Auto-Generated Physiological Chain Data for an Ontological Framework for Pharmacology and Mechanism of Action to Determine Suspected Drugs in Cases of Dysuria.

Authors:  Masayo Hayakawa; Takeshi Imai; Yoshimasa Kawazoe; Kouji Kozaki; Kazuhiko Ohe
Journal:  Drug Saf       Date:  2019-09       Impact factor: 5.606

4.  Ontology-based Vaccine and Drug Adverse Event Representation and Theory-guided Systematic Causal Network Analysis toward Integrative Pharmacovigilance Research.

Authors:  Yongqun He
Journal:  Curr Pharmacol Rep       Date:  2016-03-11

5.  Linking MedDRA(®)-Coded Clinical Phenotypes to Biological Mechanisms by the Ontology of Adverse Events: A Pilot Study on Tyrosine Kinase Inhibitors.

Authors:  Sirarat Sarntivijai; Shelley Zhang; Desikan G Jagannathan; Shadia Zaman; Keith K Burkhart; Gilbert S Omenn; Yongqun He; Brian D Athey; Darrell R Abernethy
Journal:  Drug Saf       Date:  2016-07       Impact factor: 5.606

6.  ADReCS: an ontology database for aiding standardization and hierarchical classification of adverse drug reaction terms.

Authors:  Mei-Chun Cai; Quan Xu; Yan-Jing Pan; Wen Pan; Nan Ji; Yin-Bo Li; Hai-Jing Jin; Ke Liu; Zhi-Liang Ji
Journal:  Nucleic Acids Res       Date:  2014-10-31       Impact factor: 16.971

7.  ADReCS-Target: target profiles for aiding drug safety research and application.

Authors:  Li-Hong Huang; Qiu-Shun He; Ke Liu; Jiao Cheng; Min-Dong Zhong; Lin-Shan Chen; Li-Xia Yao; Zhi-Liang Ji
Journal:  Nucleic Acids Res       Date:  2018-01-04       Impact factor: 16.971

Review 8.  Use of Biomedical Ontologies for Integration of Biological Knowledge for Learning and Prediction of Adverse Drug Reactions.

Authors:  Shadia Zaman; Sirarat Sarntivijai; Darrell R Abernethy
Journal:  Gene Regul Syst Bio       Date:  2017-03-15

9.  Harnessing ontology and machine learning for RSO classification.

Authors:  Bin Liu; Li Yao; Dapeng Han
Journal:  Springerplus       Date:  2016-09-26
  9 in total

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