Literature DB >> 2260973

Leukotriene A4 hydrolase is a zinc-containing aminopeptidase.

M Minami1, N Ohishi, H Mutoh, T Izumi, H Bito, H Wada, Y Seyama, H Toh, T Shimizu.   

Abstract

A comparison of amino acid sequences revealed that leukotriene A4 (LTA4) hydrolase is homologous to various types of aminopeptidases. Consistently with the finding, the purified LTA4 hydrolases from both human and guinea pig sources contained equimolar zinc ion, as determined by atomic absorption spectrometry. The enzyme had a significant amount of aminopeptidase activity toward synthetic peptide substrates. Both LTA4 hydrolase and aminopeptidase activities were inhibited by o-phenanthroline, p-chloromercuribenzoic acid, and Leu-thiol with similar IC50 values. Co-purification as well as co-immunoprecipitation of both enzyme activities with an affinity-purified antibody against LTA4 hydrolase strongly suggest that the two enzyme activities reside in a single protein.

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Year:  1990        PMID： 2260973     DOI： 10.1016/s0006-291x(05)80080-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

Review 1.  Leukotriene A4 hydrolase and the committed step in leukotriene B4 biosynthesis.

Authors:  J Z Haeggström
Journal:  Clin Rev Allergy Immunol       Date:  1999 Spring-Summer       Impact factor: 8.667

2.  Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378.

Authors:  M J Mueller; M Blomster; U C Oppermann; H Jörnvall; B Samuelsson; J Z Haeggström
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

3.  LTA4 hydrolase in human skin: decreased activity, but normal concentration in lesional psoriatic skin. Evidence for different LTA4 hydrolase activity in human lymphocytes and human skin.

Authors:  L Iversen; B Deleuran; A M Hoberg; K Kragballe
Journal:  Arch Dermatol Res       Date:  1996-05       Impact factor: 3.017

Review 4.  Census of cytosolic aminopeptidase activity reveals two novel cytosolic aminopeptidases.

Authors:  Nadja Akkad; Mark Schatz; Jörn Dengjel; Stefan Tenzer; Hansjörg Schild
Journal:  Med Microbiol Immunol       Date:  2012-09-14       Impact factor: 3.402

5.  Leukotriene A4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin.

Authors:  M Andberg; A Wetterholm; J F Medina; J Z Haeggström
Journal:  Biochem J       Date:  2000-02-01       Impact factor: 3.857

6.  Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity.

Authors:  K M Fukasawa; K Fukasawa; M Harada; J Hirose; T Izumi; T Shimizu
Journal:  Biochem J       Date:  1999-05-01       Impact factor: 3.857

7.  Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase.

Authors:  S Cadel; T Foulon; A Viron; A Balogh; S Midol-Monnet; N Noël; P Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

8.  Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.

Authors:  A Wetterholm; J F Medina; O Rådmark; R Shapiro; J Z Haeggström; B L Vallee; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

9.  Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice.

Authors:  Ahamed Hossain; David Heron; Ian Davenport; Thomas Huckaba; Richard Graves; Tarun Mandal; Syed Muniruzzaman; Shusheng Wang; Partha S Bhattacharjee
Journal:  Exp Eye Res       Date:  2016-06-23       Impact factor: 3.467

10.  Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis.

Authors:  J F Medina; A Wetterholm; O Rådmark; R Shapiro; J Z Haeggström; B L Vallee; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205
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