| Literature DB >> 22609357 |
Delphine Javelaud1, Marie-Jeanne Pierrat, Alain Mauviel.
Abstract
Hedgehog (HH) and TGF-β signals control various aspects of embryonic development and cancer progression. While their canonical signal transduction cascades have been well characterized, there is increasing evidence that these pathways are able to exert overlapping activities that challenge efficient therapeutic targeting. We herein review the current knowledge on HH signaling and summarize the recent findings on the crosstalks between the HH and TGF-β pathways in cancer.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22609357 DOI： 10.1016/j.febslet.2012.05.011
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124