Literature DB >> 22609142

Bringing next-generation therapeutics to the clinic through synthetic biology.

Lukasz J Bugaj1, David V Schaffer.   

Abstract

Recent advances in synthetic biology have created genetic tools with the potential to enhance the specificity, dynamic control, efficacy, and safety of medical treatments. Interfacing these genetic devices with human patients may thus bring about more efficient treatments or entirely new solutions to presently intractable maladies. Here we review engineered circuits with clinical potential and discuss their design, implementation, and validation.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22609142     DOI： 10.1016/j.cbpa.2012.04.009

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  8 in total

1.  Unique nucleotide sequence-guided assembly of repetitive DNA parts for synthetic biology applications.

Authors:  Joseph P Torella; Florian Lienert; Christian R Boehm; Jan-Hung Chen; Jeffrey C Way; Pamela A Silver
Journal:  Nat Protoc       Date:  2014-08-07       Impact factor: 13.491

2.  A universal strategy for regulating mRNA translation in prokaryotic and eukaryotic cells.

Authors:  Jicong Cao; Manish Arha; Chaitanya Sudrik; Abhirup Mukherjee; Xia Wu; Ravi S Kane
Journal:  Nucleic Acids Res       Date:  2015-04-06       Impact factor: 16.971

3.  Rapid construction of insulated genetic circuits via synthetic sequence-guided isothermal assembly.

Authors:  Joseph P Torella; Christian R Boehm; Florian Lienert; Jan-Hung Chen; Jeffrey C Way; Pamela A Silver
Journal:  Nucleic Acids Res       Date:  2013-09-26       Impact factor: 16.971

Review 4.  Genetic circuits to engineer tissues with alternative functions.

Authors:  C P Healy; T L Deans
Journal:  J Biol Eng       Date:  2019-05-03       Impact factor: 4.355

5.  Pulsed Electric Fields Alter Expression of NF-κB Promoter-Controlled Gene.

Authors:  Justina Kavaliauskaitė; Auksė Kazlauskaitė; Juozas Rimantas Lazutka; Gatis Mozolevskis; Arūnas Stirkė
Journal:  Int J Mol Sci       Date:  2021-12-31       Impact factor: 5.923

6.  Two- and three-input TALE-based AND logic computation in embryonic stem cells.

Authors:  Florian Lienert; Joseph P Torella; Jan-Hung Chen; Michael Norsworthy; Ryan R Richardson; Pamela A Silver
Journal:  Nucleic Acids Res       Date:  2013-08-27       Impact factor: 16.971

7.  Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light.

Authors:  Xianjun Chen; Ting Li; Xue Wang; Zengmin Du; Renmei Liu; Yi Yang
Journal:  Nucleic Acids Res       Date:  2015-12-15       Impact factor: 16.971

8.  Deformable Self-Propelled Micro-Object Comprising Underwater Oil Droplets.

Authors:  Taisuke Banno; Arisa Asami; Naoko Ueno; Hiroyuki Kitahata; Yuki Koyano; Kouichi Asakura; Taro Toyota
Journal:  Sci Rep       Date:  2016-08-09       Impact factor: 4.379
  8 in total

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