| Literature DB >> 22609064 |
Anastasia A Zabolotneva1, Olga Bantysh, Maria V Suntsova, Nadezhda Efimova, Galina V Malakhova, Gerald G Schumann, Nurshat M Gayfullin, Anton A Buzdin.
Abstract
SVA elements represent the youngest family of hominid non-LTR retrotransposons. Recently, a human-specific subfamily (termed SVA(F1), CpG-SVA, or MAST2-SVA) was discovered representing fusion of the CpG island-containing exon 1 of the MAST2 gene and a 5'-truncated SVA. SVA(F1) includes at least 84 members, which suggests exceptionally high retrotransposition level. We investigated if the acquirement of the MAST2 CpG-island might play a role in the success of the SVA(F1) subfamily. We observed that in 16 samples representing seven human tissues, MAST2 was cotranscribed with the members of the SVA(F1) subfamily, but not with other retrotransposons. We found that the methylation status of the MAST2-derived sequences of SVA(F1) elements reversely correlates with the transcriptional activity of MAST2. The MAST2 sequence at the 5' end of SVA(F1) acts as a positive transcriptional regulator in human germ cells. Finally, in various testicular tissue samples we uncovered a transcriptional correlation of MAST2 with the human L1, Alu and SVA retrotransposons.Entities:
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Year: 2012 PMID： 22609064 DOI： 10.1016/j.gene.2012.05.016
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688