Literature DB >> 226079

Steady-state investigations of the mechanism of histidinol dehydrogenase.

H Görisch.   

Abstract

Initial velocities of the histidinol dehydrogenase reaction (EC 1.1.1.23) were measured as a function of the concentrations of the substrates histidinol and NAD+ and in the presence and absence of the product NADH. The data are consistent with a Bi Uni Uni Bi Ping Pong mechanism. The kinetic constants of this mechanism were determined; Km for histidinol was found to be 14 microM and for NAD+ 0.7 mV; Ki for NAD+ was 0.4 mM.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 226079      PMCID： PMC1161136          DOI： 10.1042/bj1810153

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  7 in total

1.  PURIFICATION AND PROPERTIES OF HISTIDINOL DEHYDROGENASE FROM SALMONELLA TYPHIMURIUM.

Authors:  J C LOPER; E ADAMS
Journal:  J Biol Chem       Date:  1965-02       Impact factor: 5.157

2.  The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.

Authors:  W W CLELAND
Journal:  Biochim Biophys Acta       Date:  1963-01-08

3.  L-Histidinal, a biosynthetic precursor of histidine.

Authors:  E ADAMS
Journal:  J Biol Chem       Date:  1955-11       Impact factor: 5.157

4.  Acetylornithinase of Escherichia coli: partial purification and some properties.

Authors:  H J VOGEL; D M BONNER
Journal:  J Biol Chem       Date:  1956-01       Impact factor: 5.157

5.  The enzymatic synthesis of histidine from histidinol.

Authors:  E ADAMS
Journal:  J Biol Chem       Date:  1954-08       Impact factor: 5.157

6.  Purification and crystallization of histidinol dehydrogenase from Salmonella typhimurium LT-2.

Authors:  J Yourno; I Ino
Journal:  J Biol Chem       Date:  1968-06-25       Impact factor: 5.157

7.  Histidine regulatory mutants in Salmonella typhimurium. I. Isolation and general properties.

Authors:  J R Roth; D N Antón; P E Hartman
Journal:  J Mol Biol       Date:  1966-12-28       Impact factor: 5.469
  7 in total
  3 in total

Review 1.  Histidine biosynthetic pathway and genes: structure, regulation, and evolution.

Authors:  P Alifano; R Fani; P Liò; A Lazcano; M Bazzicalupo; M S Carlomagno; C B Bruni
Journal:  Microbiol Rev       Date:  1996-03

2.  Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex.

Authors:  Patrícia Soares de Maria de Medeiros; Rodrigo Gay Ducati; Luiz Augusto Basso; Diógenes Santiago Santos; Luiz Hildebrando Pereira da Silva
Journal:  Enzyme Res       Date:  2011-03-22

3.  Structures of Medicago truncatula L-Histidinol Dehydrogenase Show Rearrangements Required for NAD+ Binding and the Cofactor Positioned to Accept a Hydride.

Authors:  Milosz Ruszkowski; Zbigniew Dauter
Journal:  Sci Rep       Date:  2017-09-05       Impact factor: 4.379
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.