Literature DB >> 22607692

Levamisole receptors: a second awakening.

Richard J Martin1, Alan P Robertson, Samuel K Buxton, Robin N Beech, Claude L Charvet, Cédric Neveu.   

Abstract

Levamisole and pyrantel are old (1965) but useful anthelmintics that selectively activate nematode acetylcholine ion channel receptors; they are used to treat roundworm infections in humans and animals. Interest in their actions has surged, giving rise to new knowledge and technical advances, including an ability to reconstitute receptors that reveal more details of modes of action/resistance. We now know that the receptors are plastic and may form diverse species-dependent subtypes of receptor with different sensitivities to individual cholinergic anthelmintics. Understanding the biology of the levamisole receptors is expected to inform other studies on anthelmintics (ivermectin and emodepside) that act on ion channels.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22607692      PMCID： PMC3378725          DOI： 10.1016/j.pt.2012.04.003

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  49 in total

1.  Single-channel properties of N- and L-subtypes of acetylcholine receptor in Ascaris suum.

Authors:  Mark M Levandoski; Alan P Robertson; Shonda Kuiper; Hia Qian; Richard J Martin
Journal:  Int J Parasitol       Date:  2005-07       Impact factor: 3.981

2.  High-level pyrantel resistance in the hookworm Ancylostoma caninum.

Authors:  Steven R Kopp; Andrew C Kotze; James S McCarthy; Glen T Coleman
Journal:  Vet Parasitol       Date:  2006-09-29       Impact factor: 2.738

Review 3.  Mode of action of levamisole and pyrantel, anthelmintic resistance, E153 and Q57.

Authors:  R J Martin; A P Robertson
Journal:  Parasitology       Date:  2007       Impact factor: 3.234

4.  Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans.

Authors:  Alexander Gottschalk; Ruta B Almedom; Thorsten Schedletzky; Scott D Anderson; John R Yates; William R Schafer
Journal:  EMBO J       Date:  2005-06-30       Impact factor: 11.598

5.  Pharmacology of N-, L-, and B-subtypes of nematode nAChR resolved at the single-channel level in Ascaris suum.

Authors:  Hai Qian; Richard J Martin; Alan P Robertson
Journal:  FASEB J       Date:  2006-10-20       Impact factor: 5.191

6.  Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum.

Authors:  Johannes Haugstetter; Thomas Blicher; Lars Ellgaard
Journal:  J Biol Chem       Date:  2004-12-28       Impact factor: 5.157

7.  The cys-loop ligand-gated ion channel gene family of Brugia malayi and Trichinella spiralis: a comparison with Caenorhabditis elegans.

Authors:  Sally M Williamson; Thomas K Walsh; Adrian J Wolstenholme
Journal:  Invert Neurosci       Date:  2007-10-20

8.  The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.

Authors:  David J Simon; Jon M Madison; Annie L Conery; Katherine L Thompson-Peer; Michael Soskis; Gary B Ruvkun; Joshua M Kaplan; John K Kim
Journal:  Cell       Date:  2008-05-30       Impact factor: 41.582

9.  The Caenorhabditis elegans lev-8 gene encodes a novel type of nicotinic acetylcholine receptor alpha subunit.

Authors:  Paula R Towers; Ben Edwards; Janet E Richmond; David B Sattelle
Journal:  J Neurochem       Date:  2005-04       Impact factor: 5.372

10.  Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50.

Authors:  Stefan Eimer; Alexander Gottschalk; Michael Hengartner; H Robert Horvitz; Janet Richmond; William R Schafer; Jean-Louis Bessereau
Journal:  EMBO J       Date:  2007-09-13       Impact factor: 11.598
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  25 in total

1.  In vitro efficacy of cyclooctadepsipepdtides and aminophenylamidines alone and in combination against third-stage larvae and adult worms of Nippostrongylus brasiliensis and first-stage larvae of Trichinella spiralis.

Authors:  Daniel Kulke; Jürgen Krücken; Janina Demeler; Achim Harder; Heinz Mehlhorn; Georg von Samson-Himmelstjerna
Journal:  Parasitol Res       Date:  2012-10-02       Impact factor: 2.289

2.  Pharmacological characterization of a homomeric nicotinic acetylcholine receptor formed by Ancylostoma caninum ACR-16.

Authors:  Shivani Choudhary; James G Tipton; Melanie Abongwa; Matthew T Brewer; Jeba Jesudoss Chelladurai; Nicole Musselman; Richard J Martin; Alan P Robertson
Journal:  Invert Neurosci       Date:  2019-09-05

3.  Signaling in Parasitic Nematodes: Physicochemical Communication Between Host and Parasite and Endogenous Molecular Transduction Pathways Governing Worm Development and Survival.

Authors:  James B Lok
Journal:  Curr Clin Microbiol Rep       Date:  2016-10-07

4.  Expression of nicotinic acetylcholine receptor subunits from parasitic nematodes in Caenorhabditis elegans.

Authors:  Megan A Sloan; Barbara J Reaves; Mary J Maclean; Bob E Storey; Adrian J Wolstenholme
Journal:  Mol Biochem Parasitol       Date:  2015-12-30       Impact factor: 1.759

5.  Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy.

Authors:  Estelle Colin; Jens Daniel; Alban Ziegler; Jamal Wakim; Aurora Scrivo; Tobias B Haack; Salim Khiati; Anne-Sophie Denommé; Patrizia Amati-Bonneau; Majida Charif; Vincent Procaccio; Pascal Reynier; Kyrieckos A Aleck; Lorenzo D Botto; Claudia Lena Herper; Charlotte Sophia Kaiser; Rima Nabbout; Sylvie N'Guyen; José Antonio Mora-Lorca; Birgit Assmann; Stine Christ; Thomas Meitinger; Tim M Strom; Holger Prokisch; Antonio Miranda-Vizuete; Georg F Hoffmann; Guy Lenaers; Pascale Bomont; Eva Liebau; Dominique Bonneau
Journal:  Am J Hum Genet       Date:  2016-08-18       Impact factor: 11.025

6.  Transcriptomic evaluation of the nicotinic acetylcholine receptor pathway in levamisole-resistant and -sensitive Oesophagostomum dentatum.

Authors:  Nathan M Romine; Richard J Martin; Jeffrey K Beetham
Journal:  Mol Biochem Parasitol       Date:  2014-02-12       Impact factor: 1.759

Review 7.  Principles of agonist recognition in Cys-loop receptors.

Authors:  Timothy Lynagh; Stephan A Pless
Journal:  Front Physiol       Date:  2014-04-24       Impact factor: 4.566

8.  An integrated in vitro imaging platform for characterizing filarial parasite behavior within a multicellular microenvironment.

Authors:  Timothy Kassis; Henry M Skelton; Iris M Lu; Andrew R Moorhead; J Brandon Dixon
Journal:  PLoS Negl Trop Dis       Date:  2014-11-20

9.  Action of Carvacrol on Parascaris sp. and Antagonistic Effect on Nicotinic Acetylcholine Receptors.

Authors:  Sasa M Trailovic; Milan Rajkovic; Djordje S Marjanovic; Cédric Neveu; Claude L Charvet
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-26

10.  Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters.

Authors:  Tina Hofmaier; Anton Luf; Amir Seddik; Thomas Stockner; Marion Holy; Michael Freissmuth; Gerhard F Ecker; Rainer Schmid; Harald H Sitte; Oliver Kudlacek
Journal:  Neurochem Int       Date:  2013-12-01       Impact factor: 4.297
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