| Literature DB >> 22607674 |
Koneni V Sashidhara1, Abdhesh Kumar, Ranga Prasad Dodda, Naikade Niraj Krishna, Pooja Agarwal, Kumkum Srivastava, S K Puri.
Abstract
First synthesis of novel coumarin-trioxane hybrids is reported. The synthesis was achieved via condensation of β-hydroxyhydroperoxides with coumarinic-aldehydes in presence of p-toluenesulfonic acid in good yields and the novel hybrids were evaluated for their antimalarial activity both in vitro and in vivo.Entities:
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Year: 2012 PMID： 22607674 DOI： 10.1016/j.bmcl.2012.04.100
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823