OBJECTIVE: To determine the incidence and distribution of intervertebral disk (IVD) degeneration-related diseases in a large population of dogs of various breeds, ages, and sexes and to determine mortality rates among dogs with these diseases. DESIGN: Epidemiological study. SAMPLE: Insurance data for dogs with veterinary health-care and life insurance coverage (n = 665,249 and 552,120, respectively). PROCEDURES: Insurance claim records of 1 company in Sweden were searched to identify dogs with IVD degeneration-related diseases; incidence and mortality rates were determined for affected dogs < 12 years old and < 10 years old, respectively. Only the first paid IVD degeneration-related claim for a dog was included in incidence rate calculations. RESULTS: The incidence rate of IVD degeneration-related diseases was 27.8 (95% confidence interval [CI], 27.2 to 28.4) occurrences/10,000 dog-years at risk (DYAR), indicating that approximately 0.3% of dogs/y in this population were affected. Miniature Dachshund was the most highly represented breed, followed by Standard Dachshund and Doberman Pinscher (237.1 [95% CI, 212.9 to 261.4], 141.5 [95% CI, 135.5 to 147.4], and 88.6 [95% CI, 72.1 to 105.2] occurrences/10,000 DYAR, respectively). The incidence rate of IVD degeneration-related disease was greater in male than in female dogs and increased with age. Overall mortality rate attributed to IVD degeneration-related diseases was 9.4 (95% CI, 8.9 to 9.8) deaths/10,000 DYAR and was greater in males than in females. CONCLUSIONS AND CLINICAL RELEVANCE: Differences in incidence rates among various breeds suggested a genetic involvement. Knowledge of the distribution of IVD degeneration-related diseases among dogs of various breeds and ages may facilitate early diagnosis and preemptive treatments in patients at risk for developing these diseases.
OBJECTIVE: To determine the incidence and distribution of intervertebral disk (IVD) degeneration-related diseases in a large population of dogs of various breeds, ages, and sexes and to determine mortality rates among dogs with these diseases. DESIGN: Epidemiological study. SAMPLE: Insurance data for dogs with veterinary health-care and life insurance coverage (n = 665,249 and 552,120, respectively). PROCEDURES: Insurance claim records of 1 company in Sweden were searched to identify dogs with IVD degeneration-related diseases; incidence and mortality rates were determined for affected dogs < 12 years old and < 10 years old, respectively. Only the first paid IVD degeneration-related claim for a dog was included in incidence rate calculations. RESULTS: The incidence rate of IVD degeneration-related diseases was 27.8 (95% confidence interval [CI], 27.2 to 28.4) occurrences/10,000 dog-years at risk (DYAR), indicating that approximately 0.3% of dogs/y in this population were affected. Miniature Dachshund was the most highly represented breed, followed by Standard Dachshund and Doberman Pinscher (237.1 [95% CI, 212.9 to 261.4], 141.5 [95% CI, 135.5 to 147.4], and 88.6 [95% CI, 72.1 to 105.2] occurrences/10,000 DYAR, respectively). The incidence rate of IVD degeneration-related disease was greater in male than in female dogs and increased with age. Overall mortality rate attributed to IVD degeneration-related diseases was 9.4 (95% CI, 8.9 to 9.8) deaths/10,000 DYAR and was greater in males than in females. CONCLUSIONS AND CLINICAL RELEVANCE: Differences in incidence rates among various breeds suggested a genetic involvement. Knowledge of the distribution of IVD degeneration-related diseases among dogs of various breeds and ages may facilitate early diagnosis and preemptive treatments in patients at risk for developing these diseases.
Authors: Jackie Perino; Margaret Patterson; Mehdi Momen; Mina Borisova; Amanda Heslegrave; Henrik Zetterberg; Jordan Gruel; Emily Binversie; Lauren Baker; John Svaren; Susannah J Sample Journal: Neurosci Lett Date: 2020-12-24 Impact factor: 3.046
Authors: Rachel B Song; D Michele Basso; Ronaldo C da Costa; Lesley C Fisher; Xiaokui Mo; Sarah A Moore Journal: J Neurosci Methods Date: 2016-05-04 Impact factor: 2.390
Authors: Sarah A Moore; Nicolas Granger; Natasha J Olby; Ingo Spitzbarth; Nick D Jeffery; Andrea Tipold; Yvette S Nout-Lomas; Ronaldo C da Costa; Veronika M Stein; Linda J Noble-Haeusslein; Andrew R Blight; Robert G Grossman; D Michele Basso; Jonathan M Levine Journal: J Neurotrauma Date: 2017-03-22 Impact factor: 5.269