BACKGROUND AND PURPOSE: Cortical microinfarcts (CMIs) are detected as small foci restricted to the cerebral cortex in autopsy brains. CMIs are thought to be caused by cerebral amyloid angiopathy (CAA) in the elderly and may be a risk for dementia. We aimed to visualize CMIs, which remain invisible on conventional MRI, using double inversion recovery (DIR) and 3-dimensional fluid attenuated inversion recovery (3D-FLAIR) on 3-Tesla MRI. METHODS: We prospectively performed DIR and 3D-FLAIR images in 70 subjects with Alzheimer disease (AD; n = 47), mild cognitive impairment (n = 14), AD with cerebrovascular disease (CVD; n = 3), vascular dementia (VaD; n = 2), CAA-associated intracerebral hemorrhage (ICH; n = 2) and one each of normal pressure hydrocephalus and dementia with Lewy bodies (DLB). Susceptibility-weighted imaging (SWI) was performed to detect cerebral microbleeds (CMBs). RESULTS: Nine subjects (five of AD and one each of AD with CVD, ICH, VaD, and DLB) had small intracortical high signal lesions on both DIR and 3D-FLAIR images. All the nine subjects accompanied multiple lobar CMBs. These intracortical lesions were located in close proximity to CMBs, and were suggested to be CMIs. CONCLUSIONS: DIR and 3D-FLAIR images may open a way to visualize CMIs.
BACKGROUND AND PURPOSE: Cortical microinfarcts (CMIs) are detected as small foci restricted to the cerebral cortex in autopsy brains. CMIs are thought to be caused by cerebral amyloid angiopathy (CAA) in the elderly and may be a risk for dementia. We aimed to visualize CMIs, which remain invisible on conventional MRI, using double inversion recovery (DIR) and 3-dimensional fluid attenuated inversion recovery (3D-FLAIR) on 3-Tesla MRI. METHODS: We prospectively performed DIR and 3D-FLAIR images in 70 subjects with Alzheimer disease (AD; n = 47), mild cognitive impairment (n = 14), AD with cerebrovascular disease (CVD; n = 3), vascular dementia (VaD; n = 2), CAA-associated intracerebral hemorrhage (ICH; n = 2) and one each of normal pressure hydrocephalus and dementia with Lewy bodies (DLB). Susceptibility-weighted imaging (SWI) was performed to detect cerebral microbleeds (CMBs). RESULTS: Nine subjects (five of AD and one each of AD with CVD, ICH, VaD, and DLB) had small intracortical high signal lesions on both DIR and 3D-FLAIR images. All the nine subjects accompanied multiple lobar CMBs. These intracortical lesions were located in close proximity to CMBs, and were suggested to be CMIs. CONCLUSIONS: DIR and 3D-FLAIR images may open a way to visualize CMIs.
Authors: Susanne J van Veluw; Jaco J M Zwanenburg; Annemieke Jm Rozemuller; Peter R Luijten; Wim G M Spliet; Geert Jan Biessels Journal: J Cereb Blood Flow Metab Date: 2015-03-31 Impact factor: 6.200
Authors: Susanne J van Veluw; Jaco J M Zwanenburg; JooYeon Engelen-Lee; Wim G M Spliet; Jeroen Hendrikse; Peter R Luijten; Geert Jan Biessels Journal: J Cereb Blood Flow Metab Date: 2012-12-19 Impact factor: 6.200
Authors: Alexandra A J de Rotte; Wouter Koning; Anne G den Hartog; Sandra M Bovens; Jaco J M Zwanenburg; Dennis W J Klomp; Gerard Pasterkamp; Frans L Moll; Peter R Luijten; Gert Jan de Borst; Jeroen Hendrikse Journal: J Cereb Blood Flow Metab Date: 2014-07-30 Impact factor: 6.200
Authors: Susanne J van Veluw; Andy Y Shih; Eric E Smith; Christopher Chen; Julie A Schneider; Joanna M Wardlaw; Steven M Greenberg; Geert Jan Biessels Journal: Lancet Neurol Date: 2017-07-14 Impact factor: 44.182