Literature DB >> 22603

Estimation of the degree of crystallinity in digoxin by X-ray and infrared methods.

D B Black, E G Lovering.   

Abstract

The X-ray procedure for estimation of the degree of crystallinity in digoxin is based upon measurement of the total X-ray scattering and the scattering from crystalline regions of the drug. The infrared procedures are based upon measurement of the peak height ratios, 1775/1618 and 3095/1618 cm-1. Correlation between results obtained by the two methods is good. These methods are of value in the physico-chemical characterization of digoxin, particularly as the properties may be altered by comminution.

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Year:  1977        PMID： 22603     DOI： 10.1111/j.2042-7158.1977.tb11435.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  10 in total

1.  Detection of low levels of the amorphous phase in crystalline pharmaceutical materials by thermally stimulated current spectrometry.

Authors:  G M Venkatesh; M E Barnett; C Owusu-Fordjour; M Galop
Journal:  Pharm Res       Date:  2001-01       Impact factor: 4.200

2.  Comparative determination of polymorphs of indomethacin in powders and tablets by chemometrical near-infrared spectroscopy and x-ray powder diffractometry.

Authors:  Makoto Otsuka; Fumie Kato; Yoshihisa Matsuda; Yukihiro Ozaki
Journal:  AAPS PharmSciTech       Date:  2003       Impact factor: 3.246

3.  Quantification of crystallinity in substantially amorphous materials by synchrotron X-ray powder diffractometry.

Authors:  Cletus Nunes; Arumugam Mahendrasingam; Raj Suryanarayanan
Journal:  Pharm Res       Date:  2005-08-31       Impact factor: 4.200

4.  The quantitative analysis of crystallinity using FT-Raman spectroscopy.

Authors:  L S Taylor; G Zografi
Journal:  Pharm Res       Date:  1998-05       Impact factor: 4.200

5.  Selective imaging of active pharmaceutical ingredients in powdered blends with common excipients utilizing two-photon excited ultraviolet-fluorescence and ultraviolet-second order nonlinear optical imaging of chiral crystals.

Authors:  S J Toth; J T Madden; L S Taylor; P Marsac; G J Simpson
Journal:  Anal Chem       Date:  2012-06-27       Impact factor: 6.986

6.  Comparative evaluation of the degree of indomethacin crystallinity by chemoinfometrical Fourier-transformed [corrected] near-infrared spectroscopy and conventional powder X-ray diffractometry.

Authors:  M Otsuka; F Kato; Y Matsuda
Journal:  AAPS PharmSci       Date:  2000

7.  Formulation, in vitro dissolution, and ocular bioavailability of high- and low-melting phenylephrine oxazolidines.

Authors:  Y Qiu; J K Guillory; R D Schoenwald
Journal:  Pharm Res       Date:  1993-11       Impact factor: 4.200

8.  Evaluation of the microcrystallinity of a drug substance, indomethacin, in a pharmaceutical model tablet by chemometric FT-Raman spectroscopy.

Authors:  Takehiro Okumura; Makoto Otsuka
Journal:  Pharm Res       Date:  2005-08-03       Impact factor: 4.200

9.  Nonlinear optical imaging for sensitive detection of crystals in bulk amorphous powders.

Authors:  Umesh S Kestur; Duangporn Wanapun; Scott J Toth; Lindsay A Wegiel; Garth J Simpson; Lynne S Taylor
Journal:  J Pharm Sci       Date:  2012-07-30       Impact factor: 3.534

10.  Estimation of the degree of crystallinity of cefazolin sodium by X-ray and infrared methods.

Authors:  M S Kamat; T Osawa; R J DeAngelis; Y Koyama; P P DeLuca
Journal:  Pharm Res       Date:  1988-07       Impact factor: 4.200
  10 in total

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