| Literature DB >> 2260106 |
A E Ali1, O Arakawa, T Noguchi, K Miyazawa, Y Shida, K Hashimoto.
Abstract
A ribbon worm Cephalothrix linearis (Nemertean) showed a high toxicity, of up to 22,000 MU/g proboscis and 13,600 MU/g body, in terms of tetrodotoxin. This organism secreted the toxin from the skin when wiped with gauze. The toxin was partially purified from the secretion as well as the wiped body by ultrafiltration and Bio-Gel P-2 column chromatography. Thin-layer chromatographic, electrophoretic, high performance liquid chromatographic, and gas chromatography-mass spectrometric analyses showed that the secreted toxin was composed almost exclusively of a tetrodonic acidic-like substance, whereas the remaining toxin in the wiped body consisted of the said substance and tetrodotoxin.Entities:
Mesh：
Substances：
Year: 1990 PMID： 2260106 DOI： 10.1016/0041-0101(90)90147-y
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033