Literature DB >> 22595966

A robust, high-sensitivity stealth probe for peptidases.

Oliver Thorn-Seshold1, Monica Vargas-Sanchez, Sean McKeon, Jens Hasserodt.   

Abstract

A robust, modular fluorogenic probe system has been developed which allows the highly sensitive off-ON detection of aminopeptidase activity by releasing an exceptionally photostable, insoluble, phenolic ESIPT fluorophore. The probes generate no false positive signal in over 24 hours, but when activated give a signal within 10 minutes.

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Year:  2012        PMID： 22595966     DOI： 10.1039/c2cc32227g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe.

Authors:  Lukas Zeisel; Jan G Felber; Karoline C Scholzen; Lena Poczka; Dorian Cheff; Martin S Maier; Qing Cheng; Min Shen; Matthew D Hall; Elias S J Arnér; Julia Thorn-Seshold; Oliver Thorn-Seshold
Journal:  Chem       Date:  2022-04-14       Impact factor: 25.832

2.  In Vitro Characterization of the Colibactin-Activating Peptidase ClbP Enables Development of a Fluorogenic Activity Probe.

Authors:  Matthew R Volpe; Matthew R Wilson; Carolyn A Brotherton; Ethan S Winter; Sheila E Johnson; Emily P Balskus
Journal:  ACS Chem Biol       Date:  2019-05-13       Impact factor: 5.100

3.  Near-Infrared Aggregation-Induced Emission-Active Probe Enables in situ and Long-Term Tracking of Endogenous β-Galactosidase Activity.

Authors:  Wei Fu; Chenxu Yan; Yutao Zhang; Yiyu Ma; Zhiqian Guo; Wei-Hong Zhu
Journal:  Front Chem       Date:  2019-05-14       Impact factor: 5.221

4.  Advanced Pyrrolidine-Carbamate Self-Immolative Spacer with Tertiary Amine Handle Induces Superfast Cyclative Drug Release.

Authors:  Alberto Dal Corso; Margaux Frigoli; Martina Prevosti; Mattia Mason; Raffaella Bucci; Laura Belvisi; Luca Pignataro; Cesare Gennari
Journal:  ChemMedChem       Date:  2022-06-14       Impact factor: 3.540
  4 in total

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