Literature DB >> 22594988

mTHPC--a drug on its way from second to third generation photosensitizer?

Mathias O Senge1.   

Abstract

5,10,15,20-Tetrakis(3-hydroxyphenyl)chlorin (mTHPC, Temoporfin) is a widely investigated second generation photosensitizer. Its initial use in solution form (Foscan®) is now complemented by nanoformulations (Fospeg®, Foslip®) and new chemical derivatives related to the basic hydroxyphenylporphyrin framework. Advances in formulation, chemical modifications and targeting strategies open the way for third generation photosensitizers and give an illustrative example for the developmental process of new photoactive drugs.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 22594988     DOI： 10.1016/j.pdpdt.2011.10.001

Source DB:  PubMed          Journal:  Photodiagnosis Photodyn Ther        ISSN： 1572-1000            Impact factor:   3.631


  12 in total

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4.  Lead Structures for Applications in Photodynamic Therapy. 6. Temoporfin Anti-Inflammatory Conjugates to Target the Tumor Microenvironment for In Vitro PDT.

Authors:  Luke Rogers; Natalia N Sergeeva; Edyta Paszko; Gisela M F Vaz; Mathias O Senge
Journal:  PLoS One       Date:  2015-05-19       Impact factor: 3.240

5.  Assessing Configurational Sampling in the Quantum Mechanics/Molecular Mechanics Calculation of Temoporfin Absorption Spectrum and Triplet Density of States.

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6.  Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin.

Authors:  Mohamed S Hasanin; Mohamed Abdelraof; Mohamed Fikry; Yasser M Shaker; Ayman M K Sweed; Mathias O Senge
Journal:  Molecules       Date:  2021-06-10       Impact factor: 4.411

7.  High content screening as high quality assay for biological evaluation of photosensitizers in vitro.

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Review 8.  Porphyrin photosensitizers in photodynamic therapy and its applications.

Authors:  Jiayuan Kou; Dou Dou; Liming Yang
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9.  Lipid-DNAs as Solubilizers of mTHPC.

Authors:  Yun Liu; Jan Willem de Vries; Qing Liu; Alwin M Hartman; Gerhard D Wieland; Sebastian Wieczorek; Hans G Börner; Arno Wiehe; Eric Buhler; Marc C A Stuart; Wesley R Browne; Andreas Herrmann; Anna K H Hirsch
Journal:  Chemistry       Date:  2017-12-18       Impact factor: 5.236

10.  Temoporfin-in-Cyclodextrin-in-Liposome-A New Approach for Anticancer Drug Delivery: The Optimization of Composition.

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Journal:  Nanomaterials (Basel)       Date:  2018-10-18       Impact factor: 5.076
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